Synthetic biodegradable elastomers for drug delivery and tissue engineering

Bettinger, Christopher J.

doi:10.1351/pac-con-10-08-18

Cited by 14 publications

(11 citation statements)

References 57 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, biodegradable elastomers may be useful for the replacement of soft tissues or organs, such as blood vessels or lung, which undergo cyclic deformation 21–24 . Poly(diol citrate)s are a new class of biodegradable and biocompatible polyesters that have been proposed for use in several tissue engineering and regenerative medicine applications 25, 26 .…”

Section: Introductionmentioning

confidence: 99%

“…19,20 In particular, biodegradable elastomers may be useful for the replacement of soft tissues or organs, such as blood vessels or lungs, which undergo cyclic deformation. [21][22][23][24] Poly(diol citrate) s are a new class of biodegradable and biocompatible polyesters that have been proposed for use in several tissue engineering and regenerative medicine applications. 25,26 We recently reported the development of nitric oxide-releasing poly(diol citrate) elastomers, which were fabricated through polycondensation of citric acid, aliphatic diols, and an ethylenediaminediol that allowed the formation of diazeniumdiolate functional groups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Wang

Kibbe

2013

Biomater. Sci.

View full text Add to dashboard Cite

The delivery of nitric oxide (NO) has important applications in medicine, especially for procedures that involve the vasculature. We report photo-curable biodegradable poly(diol citrate) elastomers capable of slow release of NO. A methacrylated poly(diol citrate) macromonomer was prepared by polycondensation of citric acid with 1, 8-octanediol or 1, 12-dodecanediol followed by functionalization with 2-aminoethyl methacrylate. A miscible NO donor, diazeniumdiolated N, N-diethyldiethylenetriamine, was synthesized and incorporated into the polymer matrix. An elastomeric network was obtained via photo-polymerization of macromonomers upon UV irradiation within three minutes. Films and tubes of the NO-releasing crosslinked macromonomers exhibited strong tensile strength and radial compressive strength, respectively. They also exhibited cell compatibility and biodegradability in vitro. Sustained NO release under physiological conditions was achieved for at least one week. NO release enhanced the proliferation of human umbilical vein endothelial cells but inhibited the proliferation of human aortic smooth muscle cells. Photo-polymerizable NO-releasing materials provide a new approach for the localized and sustained delivery of NO to treat thrombosis and restenosis in the vasculature.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Wang

Kibbe

2013

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…However, many of these properties are not limited to the existing set of naturally‐derived biopolymeric materials. There is a broad range of synthetic polymers that exhibit similar enabling properties such as mechanical resiliency, optical transparency, compatibility with micron and sub‐micron scale fabrication techniques, and biodegradation on clinically relevant time scales 62–73…”

Section: Biologically‐derived Materials As Active Components In Elmentioning

confidence: 99%

Biomaterials‐Based Electronics: Polymers and Interfaces for Biology and Medicine

Muskovich¹,

Bettinger

2012

Adv Healthcare Materials

Self Cite

164

127

View full text Add to dashboard Cite

Advanced polymeric biomaterials continue to serve as a cornerstone of new medical technologies and therapies. The vast majority of these materials, both natural and synthetic, interact with biological matter without direct electronic communication. However, biological systems have evolved to synthesize and employ naturally-derived materials for the generation and modulation of electrical potentials, voltage gradients, and ion flows. Bioelectric phenomena can be interpreted as potent signaling cues for intra- and inter-cellular communication. These cues can serve as a gateway to link synthetic devices with biological systems. This progress report will provide an update on advances in the application of electronically active biomaterials for use in organic electronics and bio-interfaces. Specific focus will be granted to the use of natural and synthetic biological materials as integral components in technologies such as thin film electronics, in vitro cell culture models, and implantable medical devices. Future perspectives and emerging challenges will also be highlighted.

show abstract

“…Biodegradable polyesters have been extensively studied in the field of materials research due to their applications in drug delivery therapies, tissue engineering, and wound dressings. 1, 2 Such polymers are of particular interest given the broad range of processing methods that can be utilized for their preparation, their hydrolytic degradation, and the ability to create modulus-matched materials. 3–5 Polyesters utilized for the preparation of biomaterials such as sutures and hernia meshes include poly(lactic acid) (PLA), poly(glycolic acid) (PGA), their copolymer poly(lactic- co -glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL).…”

Section: Introductionmentioning

confidence: 99%

Biodegradable crosslinked polyesters derived from thiomalic acid and S-nitrosothiol analogues for nitric oxide release

et al. 2018

View full text Add to dashboard Cite

Crosslinked polyesters with Young’s moduli similar to that of certain soft biological tissues were prepared via bulk polycondensation of thiomalic acid and 1,8-octanediol alone, and with citric or maleic acid. The copolymers were converted to nitric oxide (NO)-releasing S-nitrosothiol (RSNO) analogues by reaction with tert-butyl nitrite. Additional conjugation steps were avoided by inclusion of the thiolated monomer during the polycondensation to permit thiol conversion to RSNOs. NO release at physiological pH and temperature (pH 7.4, 37 °C) was determined by chemiluminescence-based NO detection. The average total NO content for poly(thiomalic-co-maleic acid-co-1,8-octanediol), poly(thiomalic-co-citric acid-co-1,8-octanediol), and poly(thiomalic acid-co-1,8-octanediol) was 130 ± 39 μmol g−1, 200 ± 35 μmol g−1, and 130 ± 11 μmol g−1, respectively. The antibacterial properties of the S-nitrosated analogues were confirmed against Escherichia coli and Staphylococcus aureus. The hydrolytic degradation products were analyzed by time-of-flight mass spectrometry after a 10-week study to investigate their composition. Tensile mechanical tests were performed on the non-nitrosated polymers as well as their S-nitrosated derivatives and suggested that the materials have appropriate Young’s moduli and elongation values for biomedical applications.

show abstract

Synthetic biodegradable elastomers for drug delivery and tissue engineering

Cited by 14 publications

References 57 publications

Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery

Biomaterials‐Based Electronics: Polymers and Interfaces for Biology and Medicine

Biodegradable crosslinked polyesters derived from thiomalic acid and S-nitrosothiol analogues for nitric oxide release

Contact Info

Product

Resources

About