Synthetic bacteria with programmed cell targeting and protein injection suppress tumor growthin vivo
Alejandro Asensio-Calavia,
Carmen Mañas,
Alba Cabrera-Fisac
et al.
Abstract:Bacterial living therapeutics (BLTs) hold promise for treating cancer and other human diseases because they can be engineered and transported into the microbiota (e.g., of tumors, gastrointestinal tract) to deliver therapeutic payloads. Current approaches rely on the natural tropism of the bacterial chassis used and trigger the local release of protein cargoes, typically through active extracellular secretion or bacterial lysis. BLTs capable of targeting specific cellular subsets and delivering payloads intrac… Show more
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