Synthetic Approaches to Small- and Medium-Size Aza-Heterocycles in Aqueous Media

Singh, Girija S.; Tabane, Tumelo H.

doi:10.1016/b978-0-12-800070-0.00007-4

Cited by 3 publications

(1 citation statement)

References 97 publications

(77 reference statements)

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“…These compounds have antiviral, antibacterial, antitumor, antipsychotic, antifungal, antimicrobial, analgesic, and anticancer properties (4)(5). Some of the important medications like paclitaxel and doxepin include O-heterocycles (6).Furthermore, their applications in copolymers, flavoring agents, boosting agents, fungicides, dyestuffs, and fluorescent whiteners, make them one of the most desired substrates in the industrial sector (7). Heterocyclic compounds also control a variety of in vivo processes in the human body including eyesight, energy requirements, metabolism, and the transmission of genetic information via enzymes, DNA, and RNA (8)(9).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Heterocyclic Compounds Via 1,3-Diketones

Sharma¹,

Sharma²,

Kapoor³

2022

ECS Trans.

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Heterocyclic compounds acquire a unique place in medicinal chemistry as many of the pharmaceuticals, agrochemical industries use heterocyclic moieties in different kinds of drugs. Moreover, many of these compounds are naturally occurring and are known for their antibacterial properties from ancient times. These compounds like thiazole, pyrazole, imidazole, coumarin etc. are synthesized via 1,3-dicarbonyls as an intermediate. Essentially β-dicarbonyls are considered as promising scaffolds for the synthesis of heterocyclic compounds. Especially, due to keto-enol tautomerism, β-diketones show very distinct chemical properties. They could be made by combining an adequate methyl ketone with an acceptable ethyl ester in a Claisen reaction, which allows for a large range of potential combinations. In this review, we will discuss various synthetic approaches for the preparation of five and six membered heterocyclic compounds via 1,3-dicarbonyls.

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