Synthetic Approaches to Organic Nanoparticles

Köstler, Stefan; Ribitsch, Volker

doi:10.1002/9783527610419.ntls0251

Cited by 1 publication

(1 citation statement)

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“…Fabricating pharmaceutical nanomaterials can be achieved using top-down or bottom-up approaches. In general, the top-down approach is not suitable for processing many (APIs) due to high-shear forces involved in the mechanical milling. − In the bottom-up approach, the formation of nanostructures is performed by converting the molecular matter dissolved in liquid to particulate forms. Based on the nature and composition of the fabricated drug delivery systems (DDSs), the nanostructures are formed by self-assembly, emulsification, or precipitation. − One of the main considerations in formulating different types of polymers or APIs is to maintain the dimensions of the designed particles within a range of 100–300 nm, which is desirable for pharmaceutical applications .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Microfluidics for the Preparation of Drug and Gene Delivery Systems

Tomeh

Zhao

2020

Mol. Pharmaceutics

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Drug delivery systems (DDSs) have great potential for improving the treatment of several diseases, especially microbial infections and cancers. However, the formulation procedures of DDSs remain challenging, especially at the nanoscale. Reducing batch-to-batch variation and enhancing production rate are some of the essential requirements for accelerating the translation of DDSs from a small scale to an industrial level. Microfluidic technologies have emerged as an alternative to the conventional bench methods to address these issues. By providing precise control over the fluid flows and rapid mixing, microfluidic systems can be used to fabricate and engineer different types of DDSs with specific properties for efficient delivery of a wide range of drugs and genetic materials. This review discusses the principles of controlled rapid mixing that have been employed in different microfluidic strategies for producing DDSs. Moreover, the impact of the microfluidic device design and parameters on the type and properties of DDS formulations was assessed, and recent applications in drug and gene delivery were also considered.

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