Synthetic Approaches to New Drugs Approved During 2016

Abstract

New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to 19 new chemical entities that were approved for the first time in 2016.

Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain

“…(b) Comparison of the route found by the model trained on the USPTO dataset with the literature route for Amenamevir. 37 The model can suggest a route comparable to the literature, differing in the sequence of steps and using similar reactions to those in the literature. The predicted route is found in 3.26 seconds.…”

“…† The route predicted using the model trained on the USPTO dataset to Amenamevir is compared to the literature route. 37 Both routes vary in the order of the steps they take, with the predicted route preferring a standard amide coupling over the amide Schotten-Baumann. However, the predicted route displays reactivity conicts as deprotonation of the amine in the second step competes with the amide coupling.…”

4‐Methyltetrahydropyran (4‐MeTHP): Application as an Organic Reaction Solvent

“…[3,4,6,7] However,t hese solvents are still commonly and widelyu sed in many laboratories because there are no alternatives effective enough for certain reaction cases.E ven in recent industrial processes to make pharmaceuticals,DCM is still occasionally used. [53,54] We therefore studied the application of 4-MeTHPi nr eactions where DCM is typically adopted, specifically,i no xidation, epoxidation, condensation, and olefin metathesis reactions (Scheme 10).…”

Electrochemical and Scalable Dehydrogenative C(sp3)−H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow

“…Poly‐substituted 5‐membered saturated aza‐heterocycles, particularly pyrrolidines, are a frequent structural motif in natural (Figure A) and synthetic biologically active compounds (Figure B) with a wide range of activities, including antidiabetic, antitumor and anti‐HIV properties. For example, five of the eight anti‐infective drugs approved in 2016, including an antihepatitis C drug, contain a pyrrolidine moiety . Therefore, the development of new and efficient methods to build up these structural entities is of great importance.…”

“…For example, five of the eight anti-infective drugs approved in 2016, including an antihepatitis Cd rug, contain ap yrrolidine moiety. [5] Therefore, the development of new and efficient methods to build up these structuralentitiesiso fg reat importance.…”