Synthetic Approaches to Metallic Nanomaterials

Richards, Ryan M.; Bönnemann, Helmut

doi:10.1002/3527603476.ch1

Cited by 20 publications

(16 citation statements)

References 217 publications

(257 reference statements)

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“…The synthesis of AuNPs commonly relies on methods that basically employ wet chemistry reduction techniques, as presented in other reviews 9 , 32 . Although these techniques are generally simple and fast and can support the large-scale production of AuNPs, the synthesis of uniform AuNPs with a discrete size and shape remains challenging 215 . Recently, some approaches have been reported for the controlled synthesis and modification of AuNPs.…”

Section: Technical Challenges and Recommendationsmentioning

confidence: 99%

Applications of gold nanoparticles in virus detection

2018

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Viruses are the smallest known microbes, yet they cause the most significant losses in human health. Most of the time, the best-known cure for viruses is the innate immunological defense system of the host; otherwise, the initial prevention of viral infection is the only alternative. Therefore, diagnosis is the primary strategy toward the overarching goal of virus control and elimination. The introduction of a new class of nanoscale materials with multiple unique properties and functions has sparked a series of breakthrough applications. Gold nanoparticles (AuNPs) are widely reported to guide an impressive resurgence in biomedical and diagnostic applications. Here, we review the applications of AuNPs in virus testing and detection. The developed AuNP-based detection techniques are reported for various groups of clinically relevant viruses with a special focus on the applied types of bio-AuNP hybrid structures, virus detection targets, and assay modalities and formats. We pay particular attention to highlighting the functional role and activity of each core Au nanostructure and the resultant detection improvements in terms of sensitivity, detection range, and time. In addition, we provide a general summary of the contributions of AuNPs to the mainstream methods of virus detection, technical measures, and recommendations required in guidance toward commercial in-field applications.

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Section: Technical Challenges and Recommendationsmentioning

confidence: 99%

Applications of gold nanoparticles in virus detection

2018

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“…Further, the size distribution profile of synthesized Au and Ag nanoparticles was determined using a DLS particle size analyzer. The DLS measurements display that all the nanoparticles are falling in the nanoscale range and are found to be sub 100 nm in size ( 45,53,54 . Additionally, it has been reported that the negative repulsion forces in the solution help in high stability and high dispersity of the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Engineering bioactive surfaces on nanoparticles and their biological interactions

Matur¹,

Madhyastha

Shruthi³

et al. 2020

Sci Rep

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The successful integration of nanoparticles into biomedical applications requires modulation of their surface properties so that the interaction with biological systems is regulated to minimize toxicity for biological function. In the present work, we have engineered bioactive surfaces on gold (Au) and silver (Ag) nanoparticles and subsequently evaluated their interaction with mouse skin fibroblasts and macrophages. The Au and Ag nanoparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gallate, and curcumin as reducing and stabilizing agents. The nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme activities with limited cytotoxicity and genotoxicity. We have thus developed avenues for engineering the surface of nanoparticles for biological applications.

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“…The final NP size is dependent on the reaction conditions, such as nature and quantity of reducing agents, temperature, reaction time and capping agent [41]. The capping agent controls the NP growth in terms of rate, final size and morphology, and is required to increase the colloidal stability of the synthesized AuNP, either by electrostatic stabilization or by steric hindrance [42]. Electrostatic stabilization is attained through columbic repulsion between particles possessing a layer of ions adsorbed to their surface and a second layer of counterions [43], whereas steric hindrance stabilization relies on the use of organic molecules that restrict interactions between two independent metallic cores, preventing the aggregation of the colloidal suspension [44].…”

Section: Chemical Synthesis and Implicationsmentioning

confidence: 99%

Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics

Larguinho

Canto

Cordeiro

et al. 2015

Expert Review of Molecular Diagnostics

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Non-crosslinking (NCL) approaches using DNA-modified gold nanoparticles for molecular detection constitute powerful tools with potential implications in clinical diagnostics and tailored medicine. From detection of pathogenic agents to identification of specific point mutations associated with health conditions, these methods have shown remarkable versatility and simplicity. Herein, the NCL hybridization assay is broken down to the fundamentals behind its assembly and detection principle. Gold nanoparticle synthesis and derivatization is addressed, emphasizing optimal size homogeneity and conditions for maximum surface coverage, with direct implications in downstream detection. The detection principle is discussed and the advantages and drawbacks of different NCL approaches are discussed. Finally, NCL-based applications for molecular detection of clinically relevant loci and potential integration into more complex biosensing platforms, projecting miniaturization and portability are addressed.

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Synthetic Approaches to Metallic Nanomaterials

Cited by 20 publications

References 217 publications

Applications of gold nanoparticles in virus detection

Applications of gold nanoparticles in virus detection

Engineering bioactive surfaces on nanoparticles and their biological interactions

Gold nanoprobe-based non-crosslinking hybridization for molecular diagnostics

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