Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir (“Triazavirin®”) active against SARS-CoV-2 (COVID-19)

Abstract

Fragments of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one are found in many compounds with various types of biological activities, including the antiviral drug Riamilovir (Triazavirin®), which shows an activity against SARS-CoV-2 (COVID-19). Therefore, the development...

Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19

“…Several synthetic molecules containing heterocyclic moieties are currently known for their antiviral potentials [ 6 , 7 , 8 , 9 , 10 , 11 ]. Pyrazolo[3,4- b ]pyridine nucleus is an important scaffold in a variety of marketed anxiolytic antidepressant drugs such as cartazolate, tracazolate and etazolate ( Figure 1 ).…”

A new reversible transformation of oxindolylidene derivatives of imidazothiazolotriazine into 3-[(imidazotriazin-3-yl)thio]-2-oxoquinoline-4-carboxylates

“…Nitrogen- and sulfur-containing heterocyclic structures exhibit a wide range of biological activities and are constituent parts of most drugs. 1 Thus, unsurprisingly the search for new biologically active substances is performed mainly among these heterocyclic compounds. 2 However, the discovery and synthesis of a target structure is only the initial step of this search.…”