Synthetic Approaches and Biological Activities of 4-Hydroxycoumarin Derivatives

Jung, Jae‐Chul; Park, Oee‐Sook

doi:10.3390/molecules14114790

Cited by 117 publications

(50 citation statements)

References 39 publications

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“…They exhibit cytotoxic and spasmolytic activities, and also activity against HIV virus, and analgesic, anti-arthritis, anti-inflammatory, antipyretic, antibacterial, antiviral, and anti-cancer properties. They are also useful key intermediates for many industrial products such as dyes and liquid crystals (Jung and Park 2009;Stanchev et al 2009). …”

Section: Ascomycetes Fungimentioning

confidence: 99%

Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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Natural coumarins and derivatives are compounds that occur naturally in several organisms (plant, bacteria, and fungi) consisting of fused benzene and α-pyrone rings. These compounds show high technological potential applications in agrochemical, food, pharmaceuticals, and cosmetics industries. Therefore, the need for bulk production of coumarins and the advancement of the chemical and pharmaceutical industries led to the development of synthetic coumarin. However, biotransformation process, synthetic bioengineering, metabolic engineering, and bioinformatics have proven effective in the production of natural products. Today, these biological systems are recognized as green chemistry innovation and business strategy. This review article aims to report the potential of fungi for synthesis of coumarin. These microorganisms are described as a source of natural products capable of synthesizing many bioactive metabolites. The features, classification, properties, and industrial applications of natural coumarins as well as new molecules obtained by basidiomycetes and ascomycetes fungi are reported in order to explore a topic not yet discussed in the scientific literature.

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Section: Ascomycetes Fungimentioning

confidence: 99%

Fungi as a source of natural coumarins production

Costa

Tavares

Oliveira

2016

Appl Microbiol Biotechnol

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“…In clinic, 4-hydroxycoumarin and its derivatives are widely used anticoagulant rodenticides as well as antithrombotic agents 10 . These compounds are antagonists of vitamin K and their target is vitamin K 2, 3-epoxide reductase in the liver microsomes 11 .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of 3-substituted-4-hydoxycoumarin derivatives

2017

JCBSC

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“…Biscoumarins are a large group of heterocycles with diverse, interesting and important biological and pharmaceutical activities [1][2][3][4][5] activities. In recent years and because of these important activities, several methods are reported for the synthesis of biscoumarins using a variety of catalysts and reagents [6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Introduction of W-doped ZnO nanocomposite as a new and efficient nanocatalyst for the synthesis of biscoumarins in water

et al. 2015

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W-doped ZnO nanocomposite (W-ZnO) is easily prepared and characterized using a variety of techniques including XRD, TEM, BET, ICP-OES and SEM. This reagent can be used as an efficient and heterogeneous catalyst for the preparation of biscoumarins in water under mild conditions. Easy preparation of the catalyst, mild reaction conditions, easy work-up procedure, excellent yields and short reaction times are some of the advantages of this work. In addition, in this article and for the first time, the preparation of biscoumarins from the protected derivatives of aldehydes including oximes, hydrazones and 1,1-diacetates is reported.

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Synthetic Approaches and Biological Activities of 4-Hydroxycoumarin Derivatives

Abstract: The main purpose of this review is to summarize recent chemical syntheses and structural modifications of 4-hydroxycoumarin and its derivatives, of interest due to their characteristic conjugated molecular architecture and biological activities.

Cited by 117 publications

References 39 publications

Fungi as a source of natural coumarins production

Fungi as a source of natural coumarins production

Antioxidant activity of 3-substituted-4-hydoxycoumarin derivatives

Introduction of W-doped ZnO nanocomposite as a new and efficient nanocatalyst for the synthesis of biscoumarins in water

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