Synthetic and Natural Coumarins as Antioxidants

Abstract

Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogs. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their antioxidant effects were extensively examined. In this review, plant derived coumarins and their synthetic analogs will be systematically evaluated based on their plant origin, structure-activity relationship and antioxidant efficacy. Owing their diverse effects and inconclusive results from different in vitro studies, the mechanism of their action has not yet been fully understood and the correlation of effects with chemical structure is not conclusive at the moment. It is the objective of this review will be to summarize experimental data for different coumarins used as antioxidant agents, because promising data have been reported for a series of these agents. In addition, their ability to bind metal ions represents an additional means of modulating their pharmacological responses.

Coumarin and carbazole fluorescently modified cellulose nanocrystals using a one‐step esterification procedure

“…At the same time, coumarin derivatives are important fluorescent dyes with high photoluminescence quantum efficiencies, and uses in optoelectronic materials, while they also display anti-tumoral, anti-coagulant, and anti-oxidant properties. [27][28][29][30][31] Fillponen et al covalently linked an azide-bearing fluorescent molecule in a three step reaction: TEMPO mediated oxidation was followed by propargylamine grafting by carbodiimide-mediated amide coupling followed by a Copper(I)-catalysed AzideAlkyne Cycloaddition reaction (i.e. azide-alkyne click reaction) with azido-coumarin and azido-anthracene.…”

Fluorescence quenching of 7-amino-4-methylcoumarin by different TEMPO derivatives

“…Coumarins are known to act as free radicals' scavengers [1] and antioxidants [2], as well as possessing anticancer [3], antimicrobial [4], anti-inflammatory [5,6], anti-proliferative [7], antibacterial [8], anti-HIV [9] and antifungal [10] activities. 7-Amino-4-methylcoumarin itself may be isolated from an endophytic fungus Xylaria sp., having broad antimicrobial activity.…”

Synthesis and Anti-inflammatory Activity of Novel Furochromenes

“…In addition, a broad array of other therapeutic applications of natural and synthetic coumarins has been reported in the literature, especially concerning their anti-inflammatory / antioxidant properties, [22][23][24][25] their application as neuroprotecting agents, 26 as well as in pharmacotherapy of breast cancer. 27 Furocoumarins are a class of natural and synthetic compounds used as photoreactive, antiviral, antiinflammatory agents as well as kinase inhibitors.…”