Synthetic and medicinal perspective of thiazolidinones: A review

Manjal, Sundeep Kaur; Kaur, Ramandeep; Bhatia, Rohit; Kumar, Kapil; Singh, Virender; Shankar, Ravi; Kaur, Rupinder; Rawal, Ravindra K.

doi:10.1016/j.bioorg.2017.10.014

Cited by 138 publications

(74 citation statements)

References 30 publications

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“…Releases in the public media, however, revealed reported commercial concerns with regard to success criteria, and it has since been shelved. Variants of thiazolidinones (a class of small molecule that has been very useful in drug discovery [67]) have been used clinically for unrelated purposes (rosiglitazone and pioglitazone, which are both insulin sensitizers); however, it is clear that the structure of these molecules can to be optimized for effect in inhibiting type III secretion systems in both bacteria from the genus Salmonella and Yersinia [68]. With regard to compounds that can inhibit type II fatty acid synthesis, Anthranilic acid has been used clinically previously [69] and has chemistry associated with other clinically used products.…”

Section: Therapeutics To Prevent Host Cell Subversionmentioning

confidence: 99%

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

Laws

Taylor

Russell

et al. 2019

Expert Review of Anti-infective Therapy

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Introduction: Melioidosis is a significant health problem within endemic areas such as Southeast Asia and Northern Australia. The varied presentation of melioidosis and the intrinsic antibiotic resistance of Burkholderia pseudomallei, the causative organism, make melioidosis a difficult infection to manage. Often prolonged courses of antibiotic treatments are required with no guarantee of clinical success. Areas covered: B. pseudomallei is able to enter phagocytic cells, affect immune function, and replicate, via manipulation of the caspase system. An examination of this mechanism, and a look at other factors in the pathogenesis of melioidosis, shows that there are multiple potential points of therapeutic intervention, some of which may be complementary. These include the directed use of antimicrobial compounds, blocking virulence mechanisms, balancing or modulating cytokine responses, and ameliorating sepsis. Expert commentary: There may be therapeutic options derived from drugs in clinical use for unrelated conditions that may have benefit in melioidosis. Key compounds of interest primarily affect the disequilibrium of the cytokine response, and further preclinical work is needed to explore the utility of this approach and encourage the clinical research needed to bring these into beneficial use.

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Section: Therapeutics To Prevent Host Cell Subversionmentioning

confidence: 99%

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

Laws

Taylor

Russell

et al. 2019

Expert Review of Anti-infective Therapy

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“…7,8 Among others, derivatives of ve-membered heterocyclic systems based on the core of 1,3-thiazolidine or imidazolidine have been studied due to their broad biological activity. 9,10 Of particular interest are their derivatives containing exocyclic sulfur and oxygen atoms, such as rhodanine (2-sulfanylidene-1,3-thiazolidin-4-one) 11 or 2thiohydantoin (2-sulfanylidene-1,3-diazolidin-4-one). 12 The presence of these double-bonded atoms with other functional groups results in particularly high density of binding sites for polar interactions and hydrogen bonds, which are responsible for their interesting biological properties.…”

Section: Introductionmentioning

confidence: 99%

Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity

et al. 2019

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“…The intrinsic versatility and unique physicochemical properties of the heterocycles make them a true cornerstone in the medicinal chemistry research area . Among various types of heterocyclic compounds, indole and its derivatives have been established as important medicinal agents, possessing various biological activities such as anticholinesterase , antinociceptive , antiproliferative, tuberculostatic , antiviral, antidiabetic , and antidepressant . Indole has been already seeking the attention of many researchers; as a result, wide variety of newer synthetic strategies are continuously being explored to prepare a huge number of new derivatives with better pharmacological activity as compared with existing ones.…”

Section: Introductionmentioning

confidence: 99%

Diversified Synthetic Strategies for Pyrroloindoles: An Overview

Manjal

Pathania

Bhatia

et al. 2019

Journal of Heterocyclic Chem

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In current scenario, heterocyclic compounds' role in medicinal chemistry has been tremendously increased as they possess wide number of pharmacological activities. One of the common heterocycles include indole skeleton with well‐established biological significance in field of medicinal chemistry. Fusion of indole nucleus with pyrrole heterocycle constitutes pyrroloindole scaffold, which further modifies the existing properties of indole alone. Pyrroloindole is a privileged scaffold found in various types of bioactive entities including natural compounds and exhibits wide variety of pharmacological activities like muscle relaxant, antifungal, antitumor, and antibiotic. Therefore, it is considered as attractive template for drug discovery. From several years, numbers of synthetic strategies have been reported for the synthesis of pyrroloindole and its derivatives, including also natural compounds such as amauromine, yuremamine, and chimonanthines. Here, in this review, we have tried to compile various synthetic strategies of pyrroloindole and its derivatives.

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Synthetic and medicinal perspective of thiazolidinones: A review

Cited by 138 publications

References 30 publications

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity

Diversified Synthetic Strategies for Pyrroloindoles: An Overview

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