Synthetic and biological polycations in prolongation of skin allograft survival time

Gillissen, G

doi:10.1007/bf02121287

Cited by 1 publication

(1 citation statement)

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“…Such observations include the effects of charges on regeneration in invertebrates,21.22 a m~h i b i a ,~~ and possibly mammals.24 Piezoelectric effects on bone and exogenous charge effects on osteogenesis are now recognized in both e~p e r i m e n t a l~~~~ and clinical studies.2* Charge effects also alter the ability of tumor cells to metasta~ize~~>~O and the functional ability of the immune system; the exogenous administration of polyionic substances has been shown capable of altering humoral responses3l and allograft rejection times. 32 Recently, it has been shown that thymus derived cells recognize immunogens on the basis of their overall electrical charge. 33 In addition to these effects of charges on cells, cell membrane charges have long been recognized as important in m a 1 i g n a n~y .…”

Section: Discussionmentioning

confidence: 99%

Surface charge in foreign body carcinogenesis

Andrews

Todd

Kukulinsky

1979

J. Biomed. Mater. Res.

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The importance of surface charge in foreign body carcinogenesis was evaluated by implanting in C3H/HeJ male mice, bipolar polystyrene thermoelectrets formed in variously charged electrical fields. Charged electrets had tumor rates similar to control groups. The cumulative probability of tumor development was highest in the charged electret group being 0.58 at 133 weeks after implantation. The tumor rate for all charged electrets was 27% as compared to 17% and 6% for the control groups. The latent period of tumor induction varied little between groups and averaged approximately 700 days. No conclusions regarding the tumorigenic effect of electropositive versus electronegative sides of the electret were made although the majority of tumors arose on the electronegative (body) side of the electrets. An occasional tumor (2/25) arose on both sides of a single electret. The antigenicities of tumors tested by excise and challenge techniques were weak. The immunologic relationship between top and bottom growing tumors on a single electret could not be adequately determined because of the weak antigenicity.

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Section: Discussionmentioning

confidence: 99%