Synthetic and biological identities of layered double hydroxides nanocarriers functionalized with risedronate

Vasti, Cecilia; Bedoya, Dariana Aristizábal; L, Bonnet; Ambroggio, Ernesto E.; Giacomelli, Carla E.; Rojas, Ricardo

doi:10.1016/j.clay.2020.105880

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…Blood plasma includes the three plasma proteins and solutes such as vitamins and inorganic salts. As reported previously, the protein–protein interactions were affected by a combination of proteins [ 51 , 53 ] and buffer [ 48 ], which may affect K SV .…”

Section: Resultsmentioning

confidence: 83%

“…The adsorption patterns of this study were similar to the previous report. It was reported that the plasma proteins acted as surfactants to disperse LDH nanoparticles, although the plasma proteins interacted with several LDH particles to form precipitate of agglomerate at high LDH concentrations [ 49 , 50 , 51 ]. It was thought that the LDHs were surrounded by protein corona—the coverage of protein moiety on the surface of the LDHs—even at low concentrations for the proteins.…”

Section: Resultsmentioning

confidence: 99%

“…10 nm), quenching by the energy transfer from the proteins to LDH-S(+) was not enough to explain the higher Q values compared to the adsorption ratios. It strongly suggested that the Q values accounted for the weakly bound protein corona in addition to the tightly bound protein on the LDHs, as concentration quenching by protein–protein interactions [ 51 ] is possible even for the weakly bound moiety.…”

Section: Resultsmentioning

confidence: 99%

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Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials

Yamaguchi

Kim

2022

IJMS

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Interactions between layered double hydroxide (LDH) nanomaterials and plasma proteins according to their particle size and surface charge were evaluated. The LDHs with different particle size (150, 350 and 2000 nm) were prepared by adjusting hydrothermal treatment and urea hydrolysis and subsequent organic coating with citrate, malite and serite was applied to control the surface charge (ζ-potential: −15, 6 and 36 mV). Adsorption isotherms and Stern–Volmer plots for fluorescence quenching indicated that the human blood plasma had weak interactions toward all the types of LDHs. The adsorption isotherms did not show significant differences in the size and surface charges, while the fluorescence quenching ratio increased with the increase in the surface charge, implying that electrostatic interaction played a major role in their interactions. The fluorescence quenching of three types of plasma proteins (human serum albumin, γ-globulin and fibrinogen) by the surface charge-controlled LDHs suggested that the proteins adsorbed on the LDHs with a single layer and additional proteins were weakly adsorbed to surround the LDHs with adsorbed proteins. It was concluded that the LDH nanomaterials are fairly compatible for blood components due to the protein corona while the electrostatic interaction can affect their interaction with the proteins.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials

Yamaguchi

Kim

2022

IJMS

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“…On the other hand, the zeta potentials of CO 3 –LDHs and LDH-supported Na 4 TCBPE were measured and compared (Figure c). CO 3 –LDHs had positively charged surfaces with a zeta potential of about 32.5 mV, whereas LDH-supported Na 4 TCBPE showed a reduced positive zeta potential of about 21.2 mV. The differences in zeta potential further indicated that TCBPE 4– anions were adsorbed on the surface of CO 3 –LDH via electrostatic attraction.…”

Section: Resultsmentioning

confidence: 97%

Disordered Assembly of Donors and Acceptors on Layered Double Hydroxides for High-Efficiency Chemiluminescence Resonance Energy Transfer

et al. 2021

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High-efficiency chemiluminescence (CL) resonance energy transfer (CRET) can be obtained by shortening the donor–acceptor distance and/or improving the luminescence efficiency of CRET acceptors. However, careful design and stringent experimental conditions are usually required for the ordered assembly of CRET acceptors on support materials to avoid aggregation-caused quenching problems. In this work, an aggregation-induced emission (AIE)-active fluorophore was disorderly adsorbed on the surface of layered double hydroxides (LDHs), which could exhibit high-efficiency luminescence. On the other hand, the positively charged LDHs can further adsorb peroxynitrite (ONOO–) on the surface of LDHs. Therefore, the LDH-supported AIE fluorophore could dramatically amplify weak CL signals from ONOO– donors as a result of ultra-high CRET efficiency by coupling the shorter donor–acceptor distance with efficient CRET acceptors. The proposed CL system has been successfully applied for the detection of NaNO2 in the concentration range from 1.0 to 100 μM with a detection limit as low as 0.5 μM. Satisfactory recoveries (98–106%) and good accuracy were achieved for sausage samples. Our success will open new avenues for the convenient design of high-efficiency CRET systems.

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“…In general, LDHs are considered inorganic layered materials consisting of stacks of positively charged double hydroxide layers of divalent (e.g., Mg 2+ , Zn 2+ , or Ca 2+ ) and trivalent (e.g., Al 3+ , Fe 3+ , or Cr 3+ ) metal ions, with hydrated anions among the layers to compensate for the charge (Scheme ). Because of their unique anisotropic structure, they are one of the few layered materials with a positive structural charge that enables the adsorption of negatively charged substances, such as biomolecules in delivery processes. − Besides, LDHs are also used as basic building blocks for functional materials used as catalysts , and electrodes …”

mentioning

confidence: 99%

Delamination of Layered Double Hydroxide in Ionic Liquids under Ambient Conditions

Takács

Varga

Csapó

et al. 2022

J. Phys. Chem. Lett.

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Liquid phase delamination of layered materials into single-or few-layer nanosheets leads to stable nanoscale dispersions of 2D materials. The delamination of layered double hydroxide (LDH) to double hydroxide nanosheets was studied in two ionic liquids (ILs): ethylammonium nitrate (EAN) and 1-butyl-3-methylimidazolium thiocyanate (BMIMSCN). The as-prepared lamellar structure of LDH disappeared upon dispersing it in ILs due to delamination into 2D nanosheets confirmed by X-ray scattering and diffraction techniques and further evaluated by height profile assessment of the nanoparticles by atomic force microscopy. The results showed that both the thickness and lateral size of the dispersed particles decreased in the IL-based samples, indicating that cleavage of the LDH materials can be observed in addition to delamination. The findings prove the concept of delamination of layered materials by ILs under ambient conditions�an excellent way to prepare 2D double hydroxide nanosheet dispersions in one step using nonvolatile green solvents.

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Synthetic and biological identities of layered double hydroxides nanocarriers functionalized with risedronate

Cited by 7 publications

References 39 publications

Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials

Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials

Disordered Assembly of Donors and Acceptors on Layered Double Hydroxides for High-Efficiency Chemiluminescence Resonance Energy Transfer

Delamination of Layered Double Hydroxide in Ionic Liquids under Ambient Conditions

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