Abstract:Dynamic treatment regimes (DTRs) adaptively prescribe treatments based on patients' intermediate responses and evolving health status over multiple treatment stages. Data from sequential multiple assignment randomization trials (SMARTs) are recommended to be used for learning DTRs. However, due to re‐randomization of the same patients over multiple treatment stages and a prolonged follow‐up period, SMARTs are often difficult to implement and costly to manage, and patient adherence is always a concern in practi… Show more
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