Abstract:We report the sequence-regulated radical additions of tert-alkyl radicals to two different olefins controlled
by a Cu catalyst,
which we term the “atom-transfer radical addition–substitution”
reaction. The reactions of α-bromocarbonyl compounds, such as tert-alkyl radical sources, with methacrylates and styrenes
occur in a sequence-regulated manner to give the corresponding three-component
product possessing skipped quaternary carbon centers. Our method provides
new insight into how to control the reactivities… Show more
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