Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency

Al-Ouqaili, Mushtak T.S.; Saleh, Raed Obaid; Amin, Hawraz Ibrahim M.; Jawhar, Zanko Hassan; Akbarizadeh, Majid Reza; Naderifar, Mahin; Issa, Kovan Dilawer; Gavilán, Juan Carlos Orosco; Nobre, Marcos Augusto Lima; Jalil, Abduladheem Turki; Akhavan‐Sigari, Reza

doi:10.1016/j.arabjc.2023.104704

Cited by 15 publications

(8 citation statements)

References 65 publications

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“…90 However, traditional antibiotic treatments still present significant limitations: 1) Long-term and uncontrolled use of antibiotics can cause serious harm to the body, such as liver and kidney failure, and hemolytic anemia; 2) Continued pressure on bacteria may promote the formation of resistant strains, thereby complicating treatment; 3) Bacteria may evade the killing effects of antibiotics through mechanisms such as biofilm formation and intracellular infection. [91][92][93] Therefore, these complex resistance mechanisms make the treatment of bacterial infections more challenging, and they have spurred global researchers to accelerate the development of new antibiotics and alternative treatment methods. [94][95][96] Summarizing and Looking Forward PJI, as a "catastrophic" complication following joint arthroplasty, has always been a challenge that orthopedic surgeons must overcome.…”

Section: Dovepressmentioning

confidence: 99%

Current Status and Perspectives of Diagnosis and Treatment of Periprosthetic Joint Infection

Zhou,

Yang,

Zhang

et al. 2024

IDR

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Section: Dovepressmentioning

confidence: 99%

Current Status and Perspectives of Diagnosis and Treatment of Periprosthetic Joint Infection

Zhou,

Yang,

Zhang

et al. 2024

IDR

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“…Even though antimicrobial treatment has revolutionized the management of many infectious diseases, their increasing usage, inaccurate and indiscriminate prescription, incorrect dosage and duration of therapy and the over-the-counter distribution of antimicrobials has supported the increase in resistance to antimicrobial agents. 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

Antibiogram of Escherichia coli Isolated from Dairy Cattle and in-Contact Humans in Selected Areas of Central Ethiopia

Tadesse,

Alemayehu,

Medhin

et al. 2024

VMRR

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Background Antimicrobial resistance (AMR) is a global threat to public and animal health. Escherichia coli is considered an indicator organism for monitoring AMR among gram-negative Enterobacteriaceae in humans and animals. The current study aims to assess the antibiogram profile of E. coli isolated from dairy cattle and in-contact humans in central Ethiopia and to identify risk factors associated with multidrug resistance (MDR). Methods A cross-sectional study was conducted in which 58 farms were recruited from selected districts of central Ethiopia. E. coli was isolated using standard bacteriological techniques. A total of 200 representative isolates (140 from cattle and 60 from humans in contact) were randomly selected and tested for susceptibility to a panel of 13 antimicrobials using the Kirby-Bauer disc diffusion assay. Results The highest rate of resistance was observed for sulfamethoxazole+trimethoprim (58.6%, 82/140) and amoxicillin+clavulanic acid (70.0%, 42/60) among E. coli isolates from cattle and hmans, respectively. In contrast, resistance rates in isolates from in contact humans with the cattle were 30%, 33.3%, and 66.7%, respectively. Resistance to tetracycline (p=0.02), streptomycin (p=0.03), and sulfamethoxazole+trimethoprim (p=0.007) was significantly high in E. coli isolated from cattle on commercial dairy farms than in those isolated from cattle on smallholder farms. There was no significant difference (p>0.05) in the rate of resistance between E. coli isolated from in contact humans with smallholder and commercial dairy farms. Antimicrobial use for treatment purpose (p=0.04) and non-compliance with the drug withdrawal period (p=0.03) were significantly associated with the farm-level occurrence of MDR. Conclusion A high rate of resistance was detected in E. coli isolated from the feces of dairy cattle and in-contact humans. This necessitates an effective intervention through a one-health approach and further molecular studies are required to establish source attribution.

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“…Most of them are harmless with the protective effect of the immune system, some are beneficial (probiotics), and some are pathogenic and harmful [4]. Intensive use of antibiotics in treating bacterial infections in developed countries increases antibiotic resistance and this causes serious problems [5,6]. A lipid membrane surrounds the bacterial cell called the cell membrane, which keeps nutrients, proteins, and other cytoplasm components inside the cell.…”

Section: Introductionmentioning

confidence: 99%

Investigation of cell damage of periodontopathic bacteria exposed to silver, zirconium oxide, and silicon oxide nanoparticles as antibacterial agents

Dağlıoğlu,

Yavuz,

Ertürk

et al. 2023

Micro & Nano Letters

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Antibiotic resistance is one of the biggest public health problems of our time. The nanoparticles are a powerful alternative to these antibiotics. Engineered nanoparticles show toxic effects on bacteria by different mechanisms. The bacteria–cell interaction of engineered nanoparticles exerts their toxic effects through changes in cell wall, cell membrane, and cytoplasm content/density. Thus, death occurs as a result of cell deformation. In this study, the cellular damage of silver nanoparticles, which are known to have strong antibacterial properties, and zirconium oxide and silicon oxide engineering nanoparticles, which are less known, on periodontopathic (Prevotella intermedia and Aggregatibacter actinomycetemcomitans) bacteria, were investigated by ultrastructural changes. The lysis of the cytoplasm and separation of the membrane cytoplasm were observed. Both types of bacteria treated with Ag ENP show more hollow cytoplasm than bacteria treated with the other two nanoparticles.

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Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency

Cited by 15 publications

References 65 publications

Current Status and Perspectives of Diagnosis and Treatment of Periprosthetic Joint Infection

Current Status and Perspectives of Diagnosis and Treatment of Periprosthetic Joint Infection

Antibiogram of Escherichia coli Isolated from Dairy Cattle and in-Contact Humans in Selected Areas of Central Ethiopia

Investigation of cell damage of periodontopathic bacteria exposed to silver, zirconium oxide, and silicon oxide nanoparticles as antibacterial agents

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