Synthesize and survey the drug loading efficiency of the porous nano silica modified by gelatin

Vo, Uyen Vy; Nguyen, Van Cuong; Vo, Xuan Vu Duong; Vo, Minh; Pham, Hoang Ai Le; Tran, T. T. Nha; Nguyen, Dai Hai; Nguyen, Cuu Khoa

doi:10.1088/2043-6254/ab2e6f

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Its action is based on three unrelated principles: extended drug circulation time, avoidance of RES (reticuloendothelial system) through the use of PEGylated nanoliposomes, and high and simple doxorubicin loading driven by a transmembrane ammonium sulfate gradient, which promotes drug release in the tumor. Other investigated DOX carriers include copper sulfide NPs [ 8 ], magnetite [ 9 ], and porous nanosilica [ 10 ]. However, AuNPs provide alternative approaches due to their very attractive application properties.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

et al. 2023

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Recently, targeted nanoparticles (NPs) have attracted much attention in cancer treatment due to their high potential as carriers for drug delivery. In this article, we present a novel bioconjugate (DOX–AuNPs–Tmab) consisting of gold nanoparticles (AuNPs, 30 nm) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), which exhibited specific binding to HER2 receptors. The size and shape of synthesized AuNPs, as well as their surface modification, were analyzed by the TEM (transmission electron microscopy) and DLS (dynamic light scattering) methods. Biological studies were performed on the SKOV-3 cell line (HER2+) and showed high specificity of binding to the receptors and internalization capabilities, whereas MDA-MB-231 cells (HER2−) did not. Cytotoxicity experiments revealed a decrease in the metabolic activity of cancer cells and surface area reduction of spheroids treated with DOX–AuNPs–Tmab. The bioconjugate induced mainly cell cycle G2/M-phase arrest and late apoptosis. Our results suggest that DOX–AuNPs–Tmab has great potential for targeted therapy of HER2-positive tumors.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

et al. 2023

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“…In several works [ 74 , 140 , 141 , 142 ], the antitumour drug doxorubicin was encapsulated in the pores of mesoporous silica coated with gelatin (Gel) to investigate this drug’s pH-dependent controlled release behaviour and cytotoxicity. The results showed that this pH-sensitive MSN@Gel system was highly biocompatible and had remarkable drug loading behaviour.…”

Section: Stimuli That Control Drug Releasementioning

confidence: 99%

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Kovtareva,

Kusepova,

Tazhkenova

et al. 2024

Polymers

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The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

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“…The results showed a DLE of 55.90% and a sustained release profile at physiological pH 7.4. Therefore, they concluded that DOX/PNS-gelatin NPs were a promising delivery platform for pH-responsive release of DOX [18].…”

Section: Gelatinmentioning

confidence: 99%

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

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Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

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Synthesize and survey the drug loading efficiency of the porous nano silica modified by gelatin

Cited by 3 publications

References 18 publications

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

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