Synthesis, X-ray structure, theoretical investigation, corrosion inhibition and antimicrobial activity of benzimidazole thioether and theirs metal complexes

Bouchouit, Mehdi; Said, Mohamed Elhadi; Ali, Mounira Kara; Bouacida, Sofiane; Mérazig, Hocine; Chaouche, Noreddine Kacem; Chibani, Aïssa; Zouchoune, Bachir; Belfaitah, Ali; Bouraiou, Abdelmalek

doi:10.1016/j.poly.2016.08.045

Cited by 27 publications

(5 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, all ligands and organometallic compounds showed better efficacy against the latter than the reference drug benzylpenicillin sodium. It was noted that chelation was able to modulate the bactericidal activity, while the metallic center and ligand variation among these four complexes failed to induce any significant alteration of the inhibition zone diameters [ 319 ].…”

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

show abstract

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Other studies have explored the biological activity of coordination compounds containing the benzimidazole moiety (Devereux et al, 2007). Benzimidazole-based complexes have relatively high antibacterial and antifungal power (Bouchouit et al, 2016). Their zinc complexes, in addition to their antimicrobial activity, have been used in in vitro and in vivo anticancer studies and have been shown to have an data reports important role in the chemotherapeutic process (Tabassum et al, 2012) as well as exerting a significant cytotoxic activity (Li et al, 2012).…”

Section: Structure Descriptionmentioning

confidence: 99%

Dichlorido{2-[(5-methyl-1H-pyrazol-3-yl-κN ²)methyl]-1H-1,3-benzimidazole-κN ³}zinc

et al. 2017

View full text Add to dashboard Cite

The asymmetric unit of the title complex, [ZnCl2(C12H12N4)], contains two independent molecules having similar conformations. The coordination about the ZnIIatom is distorted tetrahedral, with the geometrical constraints of the chelating ligand responsible for the observed distortion. Each of the independent molecules forms chains in the crystal through pairs of N—H...Cl hydrogen bonds, using the pyrazole and benzimidazole N—H groups as donors. The first molecule forms chains running parallel to thebaxis, while the other molecule affords the same kind of one-dimensional supramolecular structure parallel to theaaxis. The structure was refined as a two-component twin with BASF = 0.0437 (4).

show abstract

“…The ligational behavior of benzimidazole and its derivatives has been explored in coordination chemistry to form stable complexes through various modes of coordination [7]. The benzimadazolebased metal complexes exhibit broad spectrum of pharmaceutical activities, such as zinc complexes of benzimidazole find usage in anticancer activity, and reveal remarkable antimicrobial activity [8]. In addition, several benzimadazole complexes have been reported as anticancer agents [9,10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and physicochemical studies of a series of mixed-ligand transition metal complexes and their molecular docking investigations against Coronavirus main protease

Mohapatra¹,

Saikishore

Azam

et al. 2020

Open Chemistry

View full text Add to dashboard Cite

A novel series of mixed-ligand complexes of the type, [M(L1)(L2)Cl]·2H2O [L1 = 2-(α-methyl salicylidene hydrazine) benzimidazole (primary ligand), L2 = 2,2′-bipyridine (bipy; secondary ligand), M = Co(ii), Ni(ii), Cu(ii) and Zn(ii)], were based on the physicoanalytical studies. The spectroscopic findings revealed tridentate nature of the Schiff base ligand (L1) and its coordination to the metal ions via azomethine nitrogen, ring nitrogen and the deprotonated phenolic oxygen atoms. Furthermore, the synthesized compounds were evaluated for antimicrobial activity against Bacillus subtilis, Escherichia coli and Salmonella typhi microorganisms. In addition, molecular docking studies were carried out against Middle East respiratory syndrome coronavirus (PDB ID: 4ZS6) and severe acute respiratory syndrome coronavirus 2 main protease (PDB ID: 6W63).

show abstract

Synthesis, X-ray structure, theoretical investigation, corrosion inhibition and antimicrobial activity of benzimidazole thioether and theirs metal complexes

Cited by 27 publications

References 61 publications

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Dichlorido{2-[(5-methyl-1H-pyrazol-3-yl-κN ²)methyl]-1H-1,3-benzimidazole-κN ³}zinc

Synthesis and physicochemical studies of a series of mixed-ligand transition metal complexes and their molecular docking investigations against Coronavirus main protease

Contact Info

Product

Resources

About

Synthesis, X-ray structure, theoretical investigation, corrosion inhibition and antimicrobial activity of benzimidazole thioether and theirs metal complexes

Cited by 27 publications

References 61 publications

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Dichlorido{2-[(5-methyl-1H-pyrazol-3-yl-κN 2)methyl]-1H-1,3-benzimidazole-κN 3}zinc

Synthesis and physicochemical studies of a series of mixed-ligand transition metal complexes and their molecular docking investigations against Coronavirus main protease

Contact Info

Product

Resources

About

Dichlorido{2-[(5-methyl-1H-pyrazol-3-yl-κN ²)methyl]-1H-1,3-benzimidazole-κN ³}zinc