Synthesis, X-ray Structure, Hirshfeld Analysis of Biologically Active Mn(II) Pincer Complexes Based on s-Triazine Ligands

Abstract

Herein, the synthesis and antimicrobial activities of [Mn(MorphBPT)(H2O)2NO3]NO3; (1) and [Mn(PipBPT)(H2O)2NO3]NO3; (2) complexes of the pincer-type tridentate ligands MorphBPT; 4-(4,6-di(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine and PipBPT; 2-(piperidin-1-yl)-4,6-di(1H-pyrazol-1-yl)-1,3,5-triazine are presented. Both complexes have slightly distorted octahedral coordination geometry. Their molecular packing depends on O–H···O, C–H···O hydrogen bonds and anion–π stacking contacts. Hirshfeld analysis was used to quantify the different contacts. Both complexes exhibited better anti-fungal activity than the standard Fluconazole and comparable antibacterial activity to Gentamycin against Staphylococcus aureus and Escherichia coli microbes. Moreover, complexes 1 and 2 are biologically more active than the free ligands against these microbes.

A New 1D Ni (II) Coordination Polymer of s-Triazine Type Ligand and Thiocyanate as Linker via Unexpected Hydrolysis of 2,4-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine

“…In our previous work with s-triazine pincer ligands comprising two pyrazolyl arms, we reported the molecular and supramolecular structures of different metal pincer complexes with a bis-pyrazolyl-s-triazine ligand [3,6,20,[23][24][25][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. Many homoleptic and heteroleptic complexes of this type with pincer ligands and divalent and trivalent metal ions were reported to have coordination numbers ranging from five to eight.…”

“…It is noted that the coordination behavior of the pincer bis-pyrazolyl-s-triazine ligand (BPT) depends on many factors, such as the type of metal ion, reaction conditions such as medium and temperature, as well as the nature of the counter anion. In the majority of cases, the discrete pincer complexes of the bis-pyrazolyl-s-triazine ligand were obtained [3,6,20,[23][24][25]29,30,[34][35][36][37][38]41,42]. In some instances, the ligand underwent hydrolysis, either catalyzed by the medium acidity of an external acid [31] or by the Lewis acidity of the metal ion [23,[31][32][33].…”

“…Many homoleptic and heteroleptic complexes of this type with pincer ligands and divalent and trivalent metal ions were reported to have coordination numbers ranging from five to eight. 2,4-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine is an interesting N-pincer ligand that continues to receive the interest of our research group (BPT; Figure 1) and was used for the synthesis of a large number of polymeric and discrete metal (II) complexes [29][30][31][32][33][34][35][36][37][38][39][40][41][42]. It is noted that the coordination behavior of the pincer bis-pyrazolyl-s-triazine ligand (BPT) depends on many factors, such as the type of metal ion, reaction conditions such as medium and temperature, as well as the nature of the counter anion.…”

Deciphering the Mechanism of MRSA Targeting Copper(II) Complexes of NN2 Pincer-Type Ligands

“…Furthermore, the utilization of pincer complexes has risen during the past few years in different fields due to their unique orientation and stability. , Many pincer complexes are employed with different transition metals such as Au, Pt, Cu, Co, Fe, Ni, Mn, Pd, V, and Zn for their excellent antimicrobial activity. − Among them, copper complexes always showed enhanced activity. − Consider a copper pincer complex with a pyridine-based tridentate acyclic ligand that exhibited good activity against fungus and bacteria [zone of inhibition (ZoI), Candida albicans (C. albicans), 20 mm/mg] .…”

Molecular docking-assisted investigation of Pd(II) complexes carrying “SNS” pincer-type pyridine-thioether ligand as potential drug candidates against COVID-19

“…When we look at the literature, various crystal conformation properties and application areas of both thioethers and their complexes attract attention. The properties of thioether compounds include medicinal chemistry applications, catalytic activity, lubricating effect, and biological and photoluminescent properties [ [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] ]. Our aim in this study is to reveal with theoretical calculations whether the SNS-type pincer compound and its metal complexes will be effective against target proteins of SARS-CoV-2.…”