Synthesis, X-ray structure, and nuclear magnetic resonance (1H and 13C) studies of ruthenium(II) complexes containing pyrazolyl ligands

Chlorido-, aqua-, 9-ethylguanine- and 9-ethyladenine-adducts of cytotoxic ruthenium arene complexes containing O,O-chelating ligands

“…1) was synthesised by a similar procedure to that reported [25] for the synthesis of [(g 6 -p-cym)Ru(acac)Cl] (2) (Fig. 1).…”

Use of Chelating Ligands to Tune the Reactive Site of Half‐Sandwich Ruthenium(II)–Arene Anticancer Complexes

“…Complex 1, [Ru(h 6 -p-cymene)(acac)Cl] (Figure 1), was prepared according to a previously published route, [14] and its X-ray crystal structure was determined. The most interesting feature of the structure is the linking of molecules into dimers about an inversion center by pairs of strong acac oxygen···p-cymene ring CH hydrogen bonds (O···H3 2.29 , cf.…”

“…Preparation of C 15 H 21 ClO 2 Ru (1): Compound 1 was prepared following the method of Carmona et al [14] [{Ru(h 6 -p-cymene)Cl 2 } 2 ] (250 mg, 0.41 mmol) and sodium acetylacetonate monohydrate (150 mg, 1.07 mmol) were stirred in acetone (25 mL) at 298 K for 50 min. The solution was then removed in vacuo on a rotary evaporator and the product was extracted with dichloromethane (4 5 mL).…”

Pyrazole Complexes and Supramolecular Chemistry

“…[28] Using mononuclear pyrazolato complexes as metalloligands for a second metal center (which can be different from the first) or reacting mononuclear pyrazole complexes with a suitable metal precursor in the presence of a base can serve as a rational synthetic procedure for the stepwise synthesis of binuclear (including heterobinuclear) complexes. [28][29][30] Pyrazolato ligands can abstract protons from carboxylic acids without cleavage of the N-metal bonds; the resulting cationic pyrazole complexes form strong, charge-assisted, N-H···O hydrogen bonds with the carboxylato anions (Figure 7). [31] A few complexes are known in which both a bridging pyrazolato ligand and a monodentate pyrazolato or pyrazole ligand coexist, and the dynamic processes interconverting the two ligands have been studied.…”