Synthesis, X-ray, spectroscopic characterization, DFT and antioxidant activity of 1,2,4-triazolo[1,5-a]pyrimidine derivatives

Ionic Liquid Supported on Magnetic Graphene Oxide as a Highly Efficient and Stable Catalyst for the Synthesis of Triazolopyrimidines

“…In addition, they are valuable building blocks for the structure of many herbicides such as penoxsulam, diclosulam, flumetsulam, azafenidin, and floransulan. [41][42][43][44][45] Furthermore, triazolopyrimidines are synthetic analogs of purines and nucleosides. Also, [1,2,4]triazolo [1,5-a]pyrimidines, a subtype of bioisosteric purine analogs, have been reported to possess potential antitumor activities, particularly those bearing functional groups at C-5, C-6, or C-7 positions.…”

New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease MPro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies

“…Moreover, NO scavenging is crucial for maintaining proper physiological balance; NOS enzymes play a key role in NO production, and their dysregulation can contribute to various diseases. , Effective scavenging of NO helps regulate its levels and prevent associated pathological conditions . The DPPH antioxidant potential of pyrimidines has also been significantly explored. , Through their structural features and electron-donating abilities, pyrimidines can effectively neutralize DPPH radicals, highlighting their promising role as antioxidant agents with potential applications in health and medicine . Furthermore, in contemporary research, the biological evaluation of pyrimidines holds immense significance in drug discovery .…”

Efficient Four‐Component Synthesis of 1,2,4‐Triazolo[1,5‐a]pyrimidines and Their In Vitro Antiproliferative Studies

“…The antitumor properties of 1,2,4‐Triazolo[1,5‐ a ]pyrimidines are well recognized [16–18] and are associated with [4,3‐ a ], [4,3‐ c ], [1,5‐ c ] systems [19–21] . A large number of TPs also exhibit antiviral, [22] anti‐Alzheimer's property, [23] and as CRFI receptor antagonist, [24] Further, they also exhibit antibacterial, [25] antioxidant, [26] antimalarial, [27] antifungal, [28] antidiabetic, [29] activity and as agrochemical agents [30] …”

“…[8][9][10][11][12][13][14][15] The antitumor properties of 1,2,4-Triazolo[1,5-a]pyrimidines are well recognized [16][17][18] and are associated with [4,3-a], [4,3-c], [1,5-c] systems. [19][20][21] A large number of TPs also exhibit antiviral, [22] anti-Alzheimer's property, [23] and as CRFI receptor antagonist, [24] Further, they also exhibit antibacterial, [25] antioxidant, [26] antimalarial, [27] antifungal, [28] antidiabetic, [29] activity and as agrochemical agents. [30] Keeping in view the biological importance of TPs we synthesized a new class of thioalkylated (benzyl/phenacyl) 1,2,4-Triazolo [1,5-a]pyrimidine analogues under multicomponent approach(MCR) which is an effective and reliable green approach.…”