Synthesis, thermogravimetric, and spectroscopic characterizations of three palladium metal(II) ofloxacin drug and amino acids mixed ligand complexes as advanced antimicrobial materials

Naglah, Ahmed M.; Al‐Omar, Mohamed A.; Almehizia, Abdulrahman A.; Alkahtani, Hamad M.; Bhat, Mashooq A.; Al-Shakliah, Nasser S.; Belgacem, Kaouther; Majrashi, Badriah M.; Refat, Moamen S.; Adam, Abdel Majid A.

doi:10.1016/j.molstruc.2020.129102

Cited by 17 publications

(7 citation statements)

References 45 publications

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“…Three Pd(II) complexes containing Pd(II) ion, ofloxacin drug, and amino acid (glycine or alanine) where synthesized according to the literature method [40]. These Complex I, [Pd(OFL)(Gly)]Cl was prepared by adding a hot methanolic solution (2 mmol, 40 mL, 0.722 g) of OFL to an aqueous solution (2 mmol, 25 mL, 0.354 g) of PdCl 2 and glycine (2 mmol, 5 mL, 0.150 g).…”

Section: Synthesis Of the Pdo Materialsmentioning

confidence: 99%

Synthesis, characterization, and photocatalytic efficiency of a new smart PdO oxide nanomaterials for using in the recycling and sustainable wastewater treatment

Refat¹,

Saad²,

Gobouri³

et al. 2021

Bull. Chem. Soc. Eth.

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Nanostructured PdO materials with promising catalytic properties were successfully synthesized by the controlled thermal decomposition in air of three Pd(II) complexes containing Pd(II) ion, ofloxacin drug and amino acid. The Pd(II) complexes which were used as precursors were [Pd(OFL)(Gly)]Cl, [Pd(OFL)(Ala)]Cl, and [Pd(OFL)2]Cl2, where Gly is glycine amino acid, Ala is alanine amino acid, and OFL is ofloxacin. Structural and morphological properties of the synthesized PdO materials were obtained using FTIR, XRD, SEM, and EDX techniques. The XRD results confirm the tetragonal structure of PdO. The obtained PdO materials were tested as a catalyst for the heterogeneous degradation of H2O2 solution. The results revealed that PdO could effectively degrade H2O2. KEY WORDS: PdO, Nanoparticles, Photocatalytic efficiency, Wastewater treatment Bull. Chem. Soc. Ethiop. 2021, 35(1), 107-118. DOI: https://dx.doi.org/10.4314/bcse.v35i1.9

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Section: Synthesis Of the Pdo Materialsmentioning

confidence: 99%

Synthesis, characterization, and photocatalytic efficiency of a new smart PdO oxide nanomaterials for using in the recycling and sustainable wastewater treatment

Refat¹,

Saad²,

Gobouri³

et al. 2021

Bull. Chem. Soc. Eth.

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“…Investigations regarding the use of transition metal complexes as medicines for human diseases have shown important advances, with transition metal complexes being the most widely used as chemotherapeutic agents. Research in nanotechnology allows the development of nanomaterials below 100 nm, the specific physical and chemical properties of nanomaterials being common in all fields [6][7][8]. Studies showed that nanocomposites have distinct physical, chemical, and biological applications.…”

Section: Figure 2 Tem Images Of [Zr(cap)(h2o)3] • 7 H2o Complexmentioning

confidence: 99%

“…COOH, C=O, SH and proline nitrogen [2][3][4]. Mineral ions are important in the functioning of the vital functions of living organisms as they occur under the form of complex groups or chelates, as well as for methods of analysing and controlling medicinal substances by forming complexes [3][4][5][6][7][8]. In various pH media, zinc(II) captopril complexes have been synthesized and characterized by many authors [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Ftir, 1h Nmr, Tga, Tem and Biological Studies on the New Synthesized Nano Zirconium(iv) Captopril Hypertension Drug Complex

ALIBRAHIM¹

2022

FARMACIA

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Captopril (H2cap) is currently used to treat arterial hypertension and some types of congestive heart failure and to prevent kidney failure due to high blood pressure and diabetes. In an alkaline medium, a new zirconium(IV) complex was synthesized through the chemical reaction between H2cap drug ligand and Zr(SO4)2 • H2O hydrated salt in a ratio of 1:1 (metal:ligand). The structure interpretation of Zr(IV) complex has been confirmed using microanalytical analysis, molar conductance, infrared (FTIR) and proton nuclear magnetic resonance ( 1 H NMR) spectra, thermogravimetric (TGA) and differential thermogravimetric (DrTGA) analysis. Spectroscopic analysis of the synthesized Zr(IV) complex in solid state form showed that the coordination occurs through the oxygen of carboxylate COO and amido groups C=O, as well as sulphur atom of -SH group. The H2cap ligand acts as a tridentate chelate after the deprotonation of both hydrogen atoms from the ligand in an alkaline medium, with the presence of three water molecules inside the coordination sphere of the complex. These results are supported by elemental analysis as well as by molar conductance and TGA/DrTGA measurements. The experimental results revealed that the Zr(IV) complex has an approximate octahedral geometry around zirconium metal ion with formula [Zr(cap)(H2O)3] • 7 H2O. Nanoscale of the synthesized complex was studied by transmission electron microscopy (TEM). The antimicrobial efficiency of Zr(IV) complex was carried out against Escherichia coli, Bacillus subtilis and antifungal (Aspergillus niger and Aspergillus flavus). RezumatCaptoprilul (H2cap) este folosit pentru a trata hipertensiunea arterială și unele tipuri de insuficiență congestivă a inimii, dar și pentru a preveni insuficiența renală provocată de hipertensiunea arterială și diabet. În mediu alcalin, a fost sintetizat un nou complex de zirconiu(IV), prin reacția chimică dintre ligandul H2cap și sarea hidratată Zr(SO4)2 • H2O în raport 1:1 (metal: ligand). Structura complexului Zr(IV) a fost confirmată folosind analiza microanalitică, conductanța molară, spectrele în infraroșu (FTIR) și de rezonanță magnetică nucleară de protoni ( 1 H RMN), analiza termogravimetrică (TGA) și termogravimetria diferențială (DrTGA). Analiza spectroscopică a complexului Zr(IV) sintetizat în stare solidă a demonstrat coordonarea prin oxigenul carboxilat COO și grupările amido C=O, precum și prin atomul de sulf al grupării -SH. Ligandul H2cap acționează ca un chelat tridentat, după deprotonarea ambilor atomi de hidrogen din ligand, într-un mediu alcalin cu prezența a trei molecule de apă în interiorul sferei de coordonare a complexului. Aceste rezultate sunt susținute de analiza elementală, precum și de măsurători ale conductanței molare și TGA/DrTGA. Rezultatele experimentale au arătat că acest complex prezintă o geometrie octaedrică aproximativă în jurul ionului metalic de zirconiu cu formula [Zr(cap)(H2O)3] • 7 H2O. Scala nanometrică a complexului sintetizat a fost studiată prin microscopie electronică de transmisie (TE...

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“…The characterization experiments showed that the molar ratio of the complexes was as follows 1:2 [Pd(OFL)2]Cl2 and 1:1:1 as [Pd(OFL)(AA)]Cl. Moreover, spectroscopic data indicated the OFL ligand as a bidentate ligand which coordinates using the nitrogen atoms of the piperazine ring [84]. Finally, these complexes antibacterial activity was studied against K. pneumoniae, E. coli, S. aureus, and Staphylococcus epidermidis.…”

Section: Nickel Compounds As Antimicrobial Agentsmentioning

confidence: 99%

“…Thus, increasing the possible π-electron delocalization over the metal complex, which may increase the lipophilic character of the metal complex. This then favours the metal complexes permeation into the cell wall and cell membrane [84].…”

Section: Nickel Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Untitled

2022

J. Med. Chem. Sci.

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Synthesis, thermogravimetric, and spectroscopic characterizations of three palladium metal(II) ofloxacin drug and amino acids mixed ligand complexes as advanced antimicrobial materials

Cited by 17 publications

References 45 publications

Synthesis, characterization, and photocatalytic efficiency of a new smart PdO oxide nanomaterials for using in the recycling and sustainable wastewater treatment

Synthesis, characterization, and photocatalytic efficiency of a new smart PdO oxide nanomaterials for using in the recycling and sustainable wastewater treatment

Ftir, 1h Nmr, Tga, Tem and Biological Studies on the New Synthesized Nano Zirconium(iv) Captopril Hypertension Drug Complex

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