Synthesis, thermal and spectroscopic behaviors of metal–drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes

Refat, Moamen S.; Al-Maydama, Hussein M.A.; Al-Azab, Fathi M.; Amin, Ragab R.; Jamil, Yasmin M.S.

doi:10.1016/j.saa.2014.02.160

Cited by 30 publications

(14 citation statements)

References 78 publications

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“…Thermodynamic activation parameters of decomposition processes of samples, namely activation energy, enthalpy, entropy, and Gibbs free energy change of the decomposition were evaluated graphically in Figure by employing the Coats‐Redfern relation for complexes 1 , 2 , 3 and 4 . Data for kinetic thermal studies were shown in Table .…”

Section: Resultsmentioning

confidence: 99%

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

Rajeshwari

Vasantha

Kumar

et al. 2019

Applied Organom Chemis

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The Nickel (II) complexes [Ni(Cl)2(metf)(o‐phen)] (1), [Ni(Cl)2(metf)(opda)] (2), [Ni(Cl)2(metf)(en)](3), [Ni(Cl)2(metf)(2,2'‐bipy)](4), (metf = metformin, o‐phen = ortho‐phenanthroline, opda = ortho‐phenylenediamine, en = ethylenediamine, 2–2′ bipy = 2–2′ bipyridyl) were synthesized and characterized using LC–MS, elemental analysis, molar conductance measurements, TGA‐DTA, IR spectroscopy, magnetic moment measurements and electronic spectroscopy. The central Ni2+ was found to be in octahedral geometry. The DNA interaction of these complexes have been studied by UV–visible absorption studies, fluorescence emission technique and viscosity measurement. The complexes showed absorption hyperchromism in UV–visible spectra with calf thymus DNA. The binding constants from UV–visible absorption studies were 7.42 × 104, 0.74 × 104, 3.19 × 104, 5.9 × 104 M−1 for 1, 2, 3 and 4, respectively and Stern‐Volmer quenching constants from fluorescence studies were 0.16, 0.41, 0.23, 0.18, respectively. Viscosity measurements revealed that the binding of the complexes with DNA could be surface binding, mainly due to groove binding. The highest DNA cleavage activity of the complexes is recorded for complex 1. The complexes were docked in to B‐DNA sequence, 5′(D*AP*CP*CP*GP*AP*CP* GP*TP*CP*GP*GP*T)‐3′ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software. C Docker Intectraction energy of 1, 2, 3 and 4 complexes is 32.027, 31.427, 35.393 and 30.521 respectively. The highest docking score is seen for complex 3.

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Section: Resultsmentioning

confidence: 99%

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

Rajeshwari

Vasantha

Kumar

et al. 2019

Applied Organom Chemis

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“…In this study, thermal analysis was carried out by using TGA Q 5000 V3.13 build 261 instruments. For the thermal degradation of the complexes, the kinetic and thermodynamic parameters i.e., activation energy (E a ), enthalpy (ΔH), entropy (ΔS) and free energy changes (ΔG) were evaluated by employing the most popular Coats‐Redfern relation [Figure ] for complexes 1, 2, 3 . Data for kinetic thermal studies were shown in (Table ).…”

Section: Resultsmentioning

confidence: 99%

Chromium‐metformin ternary complexes: Thermal, DNA interaction and Docking studies

Shekhar

Vasantha

Kumar

et al. 2019

Applied Organom Chemis

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Three chromium ternary complexes with metformin (met) as a primary ligand and bipyridine (bipy) or ortho‐phenylenediamine (opda) or ortho‐phenanthroline (phen) as secondary ligand were synthesized. These complexes [Cr (Cl)2(Hmet)(bipy)]‐(1), [Cr (Cl)2(Hmet)(opda)]‐(2) and [Cr (Cl)2(Hmet)(phen)]‐(3) were characterized by LC–MS, elemental analysis, molar conductance, thermal analysis, infrared spectroscopy, electronic spectroscopy. The geometrical structures have been found to be octahedral. Degradation pattern of the compounds is shown by thermal studies. The Kinetic parameters‐ energy of activation (Ea), enthalpy (ΔH), entropy (ΔS) and free energy changes (ΔG) have been determined by thermogravimetric data. Coats‐Redfern integration method with thirteen kinetic models was used to calculate the kinetic and thermodynamic parameters for the degradation of all the complexes. The stabilities of the complexes were obtained from their molecular orbital structures from which the quantum chemical parameters were calculated using the HOMO‐LUMO energies. UV–Visible absorption, fluorescence, and viscosity measurements have been conducted to assess the interaction of the complexes with CT DNA. The complexes showed absorption hyperchromism in its UV–Vis spectrum with DNA. The binding constants Kb from UV–Vis absorption studies were 3.1x104, 4.4x104, 5x104 M−1 for 1, 2, 3 respectively and Stern–Volmer quenching constants (Ksq) from fluorescence studies were 0.137, 0.532, 0.631 for 1, 2, 3 respectively. Finally, viscosity measurements revealed that the binding of the complexes with CT‐DNA could be surface binding, mainly due to groove binding. The activity of complexes towards DNA cleavage decrease in the order of 3 > 2 > 1.The light switching properties of the complexes were also evaluated. The complexes were docked in to B‐DNA sequence, 5′(D*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)‐3′ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software.

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“…Several reports in coordination biochemistry have shown that soluble iron and other transition metals can complex antibiotic molecules [24][25][26]. Amoxicillin, for example, is reported to form complexes with aqueous Fe(II), Fe(III), Co(II), Co(III), Ni(II), Cu(II) and Zn(II) [27], and La(III), Ce(III), Sm(III) and Y(III) [26,27].…”

Section: Introductionmentioning

confidence: 99%

“…Amoxicillin, for example, is reported to form complexes with aqueous Fe(II), Fe(III), Co(II), Co(III), Ni(II), Cu(II) and Zn(II) [27], and La(III), Ce(III), Sm(III) and Y(III) [26,27]. However, this complexation property has not been used to produce adsorbents.…”

Section: Introductionmentioning

confidence: 99%

Role of [FeOx(OH)y] surface sites on the adsorption of β-lactamic antibiotics on Al2O3 supported Fe oxide

Pinto

Medeiros

Ardisson

et al. 2016

Journal of Hazardous Materials

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Synthesis, thermal and spectroscopic behaviors of metal–drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes

Cited by 30 publications

References 78 publications

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

Water Soluble Nickel – metformin ternary complexes: Thermal, DNA binding and molecular docking studies

Chromium‐metformin ternary complexes: Thermal, DNA interaction and Docking studies

Role of [FeOx(OH)y] surface sites on the adsorption of β-lactamic antibiotics on Al2O3 supported Fe oxide

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