Synthesis, structures, electrochemical characterizations, theoretical and anticancer studies of Pd(II)-, Pt(II)- NHC complexes

Mondal, Ambarish; Behera, Subhadarshinee; Kisan, Hemanta K.; Isab, Anvarhusein A.; Chandra, Swapan K.; Sultana, Jasmine; Banerjee, Saptak; Dinda, Joydev

doi:10.1016/j.ica.2023.121796

Inorganica Chimica Acta

2024

DOI: 10.1016/j.ica.2023.121796

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Synthesis, structures, electrochemical characterizations, theoretical and anticancer studies of Pd(II)-, Pt(II)- NHC complexes

Ambarish Mondal,

Subhadarshinee Behera,

Hemanta K. Kisan

et al.

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2024

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Cited by 3 publications

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Design, Synthesis and Bioactivity Evaluation of Ag(I)‐, Au(I)‐ and Au(III)‐Quinoxaline‐Wingtip N‐Heterocyclic Carbene Complexes Against Antibiotic Resistant Bacterial Pathogens

Sahu,

Mandal,

Biswas

et al. 2024

ChemMedChem

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Intending to homogenize the biological activities of both quinoxaline and imidazole moieties, the proligand, 1‐methyl‐3‐quinoxaline‐imidazolium hexaflurophosphate (1.HPF6), and [Ag(1)2][PF6], (2); [Au(1)2][PF6], (3); and [Au(1)Cl3], (4) NHC complexes were synthesized. All the synthesized compounds were characterized by elemental analysis, NMR, and UV‐Vis spectroscopy. Finally, single crystal X‐ray structures revealed a linear geometry for complex 2 whereas a square planar geometry for complex 4. The formation of complex 3 was confirmed and supported by its MS spectra. The antibacterial activities of all the synthesized complexes were investigated against gram‐positive bacteria and gram‐negative bacteria. The Au(III)‐NHC complex, 4 showed the highest antibacterial activity with extremely low MIC values against both the bacterial strains (0.24 µg.mL‐1). Monitoring of zeta potential supports the higher activity of complex 4 compared to 2 and 3. ROS production by complex 4 has also been measured in vitro in the CT26 cancer cell lines, which is directly responsible for targetting and killing the bacterial pathogens. Cell cytotoxicity assay using 293T cell lines has been performed to investigate the biocompatibility nature of complex 4. Also, an excellent hemocompatibility was assigned to it from its hemolytic studies, which provide valuable insights into the design of novel antibacterial agents.

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Design, Synthesis and Bioactivity Evaluation of Ag(I)‐, Au(I)‐ and Au(III)‐Quinoxaline‐Wingtip N‐Heterocyclic Carbene Complexes Against Antibiotic Resistant Bacterial Pathogens

Sahu,

Mandal,

Biswas

et al. 2024

ChemMedChem

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show abstract

An unusual CAr^CNHC- and bidentate NAr^CNHC-cyclometalated Re(I)-NHC complexes with quinoline-functionalized ligands: Syntheses, structures, and blue-luminescent properties

Gao,

Luo,

et al. 2024

Journal of Molecular Structure

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One-Step Synthesis of 5-Acetyl-1,3-dibenzyl-5-(ethoxycarbonyl)-3,4,5,6-tetrahydropyrimidinium Nitrate

Gibadullina,

Murinov,

Musin

et al. 2024

Russ J Gen Chem

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Synthesis, structures, electrochemical characterizations, theoretical and anticancer studies of Pd(II)-, Pt(II)- NHC complexes

Cited by 3 publications

References 47 publications

Design, Synthesis and Bioactivity Evaluation of Ag(I)‐, Au(I)‐ and Au(III)‐Quinoxaline‐Wingtip N‐Heterocyclic Carbene Complexes Against Antibiotic Resistant Bacterial Pathogens

Design, Synthesis and Bioactivity Evaluation of Ag(I)‐, Au(I)‐ and Au(III)‐Quinoxaline‐Wingtip N‐Heterocyclic Carbene Complexes Against Antibiotic Resistant Bacterial Pathogens

An unusual CAr^CNHC- and bidentate NAr^CNHC-cyclometalated Re(I)-NHC complexes with quinoline-functionalized ligands: Syntheses, structures, and blue-luminescent properties

One-Step Synthesis of 5-Acetyl-1,3-dibenzyl-5-(ethoxycarbonyl)-3,4,5,6-tetrahydropyrimidinium Nitrate

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