Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters

Synthesis and characterization of the ligand based on benzoxazole and its transition metal complexes: DNA-binding and antitumor activity

“…Moreover, Cu-L showed much higher antitumor activity than other complexes did on all the cell lines. To our best knowledge, although the antitumor activity of copper complex is no better than cisplatin, its IC 50 values in a lM range are pretty well, considering that of other complexes reported recently [62][63][64][65][66]. The cytotoxicity displayed by Ni-L and Co-L were comparable, with Ni-L slightly over Co-L except for A549.…”

Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity

“…Among them, [Pt(dpaOH)X 2 ] complexes (X 2 =2Cl − , ox, malonate, cyclobutane-1,1′-dicarboxylate or 3-hydroxycyclobutane-1,1′-dicarboxylate; dpaOH = 2-hydroxy-1,3-diaminopropane) showed higher in vitro cytotoxicity against the gastric cancer cell line (SGC-7901), human prostate cancer cell line (LNcap) cancer cells and both sensitive and resistant human lung cancer cell line (A549 and A549/ATCC) as compared to carboplatin [17]. The complex trans-[Pt(tce) 2 (pta) 2 ], involving the thiocarbamate ester of the SC (OMe)= NC 6 H 4 Cl composition (tce) and 1,3,5-triaza-7-phosphaadamantane (pta), was determined to be more active than cisplatin against human ovarian carcinoma cells (SK-OV-3) and human colon carcinoma (HT29) [18]. In the case of [Pt(pyrr)Cl 2 ] complex, where pyrr stands for both 2(S)-aminomethylpyrrolidine and 2(R)-aminomethylpyrrolidine enantiomers, the in vitro cytotoxicity against human ovarian carcinoma cells (A2780) is comparable with cisplatin, while it was determined as higher than that of cisplatin against A2780R cells (a cisplatin-resistant counterpart of A2780) [19].…”

Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates

“…It is worth noting, that in contrast to the thiocarbamate esters, the thiocarbamates did not seem to form neutral complexes of the type trans-[Pt{SC(NR′) = NC 6 H 4 R} 2 (PTA) 2 ] [15]. If two equivalents of the 4-ClC 6 H 4 NHC(S)NMe 2 were used in the reaction, a material was obtained which we believe to be the salt cis-[Pt{SC(NMe 2 ) = NC 6 H 4 Cl}(PTA) 2 ] [SC(NMe 2 ) = NC 6 H 4 Cl], based on 1 H NMR spectroscopy as well as positive and negative mode ES-MS data.…”

“…Given that complexes of other transition metals, in particular gold, containing phosphines and thiolate ligands are cytotoxic [8][9][10], it is somewhat surprising that analogous platinum compounds have so far not been examined much. We and others have previously reported the preparation and cytotoxicity some gold, palladium and platinum complexes containing the water-soluble phosphine 1,3,5-triaza-7-phosphaadamantane (PTA) and thiolate ligands [11][12][13][14][15]. We found that trans-platinum complexes containing anionic S-coordinated thiocarbamate esters displayed considerable cytotoxic activity; however the complexes were poorly soluble in most solvents and insoluble in water [15].…”

“…We and others have previously reported the preparation and cytotoxicity some gold, palladium and platinum complexes containing the water-soluble phosphine 1,3,5-triaza-7-phosphaadamantane (PTA) and thiolate ligands [11][12][13][14][15]. We found that trans-platinum complexes containing anionic S-coordinated thiocarbamate esters displayed considerable cytotoxic activity; however the complexes were poorly soluble in most solvents and insoluble in water [15]. In an attempt to improve solubility, we decided to prepare some cationic cis-platinum analogues containing chelating thioamides and to study their cytotoxicity in a small panel of cell lines comprising cisplatinsensitive as well as primarily cisplatin-resistant human cancer cells.…”