“…Instead, a new band indicative of C=N bond is observed at 1622 cm -1 . 20,21 When compared with the spectrum of the free Schiff base HL 2 , it can be seen that the band is shifted to the lower frequency. This indicates the coordination of the imino N atom to the cobalt center.…”
Abstract). The complexes have been characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction. The L 1 ligand coordinates to the Co atom through the phenolate O and carbonyl O atoms, while the L 2 ligand coordinates to the Co atom through the phenolate O and imino N atoms. The Co atom in complex 1 adopts octahedral coordination and that in complex 2 adopts tetrahedral coordination. The effect of the free ligands and the cobalt complexes on the antimicrobial activities against Staphylococcus aureus, Escherichia coli, and Candida albicans was studied.
“…Instead, a new band indicative of C=N bond is observed at 1622 cm -1 . 20,21 When compared with the spectrum of the free Schiff base HL 2 , it can be seen that the band is shifted to the lower frequency. This indicates the coordination of the imino N atom to the cobalt center.…”
Abstract). The complexes have been characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction. The L 1 ligand coordinates to the Co atom through the phenolate O and carbonyl O atoms, while the L 2 ligand coordinates to the Co atom through the phenolate O and imino N atoms. The Co atom in complex 1 adopts octahedral coordination and that in complex 2 adopts tetrahedral coordination. The effect of the free ligands and the cobalt complexes on the antimicrobial activities against Staphylococcus aureus, Escherichia coli, and Candida albicans was studied.
“…Binding of metal ions to -SH groups results in the change of catalytic structure of active site leading to variation in enzyme activity. Most of the metal inhibition reactions of urease are non-competitive and slow binding processes (Liu et al 1995;Oehlschläger et al 1998;Zaborska et al 2001).…”
The present work describes the inhibition studies of free as well as immobilized urease by different heavy metals. Porous silicon (PS) films prepared by electrochemical etching were used for urease immobilization by physical adsorption. The enzyme was subjected to varying concentrations of Cr 6+ , Cr 3+ , Cu 2+ , Fe 2+ , Cd 2+ and Ni 2+ and analyzed for the variation in the activity. To study the effect of other heavy metals on the interaction of urease and Cr 6+ , free as well as immobilized urease was subjected to the combination of each metal ion with Cr 6+. Results proved the sensitivity of free as well as immobilized urease towards heavy metals by observed reduction in activity. Immobilized urease showed less degree of inhibition compared to free urease when tested for inhibition by individual metal ions and in combination with Cr 6+. IC 50 values were found higher for inhibition by the combination of metal ions with Cr 6+. Interaction of heavy metal ions with functional groups in active site of urease and limitations of mass transfer are the two factors responsible for the variation in activity of urease. Relation between the variation of urease activity and amount of heavy metals can be applied in biosensor development for determining the concentration of Cr 6+ present in the water samples.
“…It is also important to highlight the work of Pan and co-workers (2016) ( 42 and 43 ), Chen and co-workers ( 44 and 46), Habala and co-workers (2016) ( 45 ), Dong and co-workers (2011) ( 47 ), Cui and co-workers (2011) ( 48 ) and You and co-workers (2010) ( 49 ), who synthesized copper complexes with IC 50 values better than 1 µM, i.e., compounds with potent activities ( Fig. 7 ) [43] , [44] , [45] , [46] , [47] , [48] . Fig.…”
Section: Schiff Base Metal Complexes As Urease Inhibitorsmentioning
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