Synthesis, Structures, and Antimicrobial Activity of Zinc and Copper Complexes Derived From <i>N</i>-isopropyl-<i>N′</i>-(1-pyridin-2-ylethylidene)ethane-1,2-diamine

Hu, Xiaoming; Xue, Ling-Wei; Zhao, Gan-Qing; Han, Yong-Jun

doi:10.1080/15533174.2011.613884

Cited by 7 publications

(1 citation statement)

References 26 publications

(22 reference statements)

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“…Copper(II) complexes with pyridine derivatives ligands, i.e. 2‐picolinic acid, nicotinic acid, 2‐hydroxypyridine, 2‐aminopyridine, or Schiff base derived from 2‐acetypyridine, have shown noticeable antimicrobial activity against B. subtilis, C. albicans, S. aureus , and E.coli , …”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

Kalinowska-Lis

Szabłowska-Gadomska

Lisowska

et al. 2017

Zeitschrift anorg allge chemie

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The cytotoxic and antimicrobial activity of a series of six copper(II) complexes with phosphate and hydroxymethyl derivatives of pyridine and benzimidazole were investigated. The complexes and the corresponding free ligands were tested against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922, Proteus hauseri ATCC 13315, and Candida albicans ATCC 10231. Among the tested copper(II) complexes, compounds 2 and 5 containing 1H‐benzimidazol‐2‐ylmethyl diethyl phosphate and 2‐(hydroxymethyl)benzimidazole as ligands, respectively, were most active and limited the growth of S. aureus, E. coli, and C. albicans by 30–60 % according to concentration and microorganism. The in vitro cytotoxic activity of the CuII complexes and free ligands towards cancerous B16 (murine melanoma) and non‐cancerous 10T1/2 (murine fibroblasts) cell lines was determined. The 10T1/2 cells were treated with the compounds at concentrations equal to IC50 values for B16 cells. In spite of the use of relatively high concentrations of the complexes, the viability of 10T1/2 cells was very high, ca. 80 % in some cases. Stability of the CuII complexes was evaluated in water solutions by UV/Vis spectroscopy. The copper(II) complex of 4‐(hydroxymethyl)pyridine was synthesized and identified.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

Kalinowska-Lis

Szabłowska-Gadomska

Lisowska

et al. 2017

Zeitschrift anorg allge chemie

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Synthesis, X-ray crystal structures and thermal analyses of some new antimicrobial zinc complexes: New configurations and nano-size structures

Masoudiasl

Montazerozohori

Naghiha

et al. 2016

Materials Science and Engineering: C

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Group 12 metal complexes of (2-piperazine-1-yl-ethyl)-pyridin-2-yl-methylene-amine: rare participation of terminal piperazine N in coordination leads to structural diversity

et al. 2017

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By using a potential tridentate ligand L ((2-piperazine-1-yl-ethyl)-pyridin-2-yl-methylene-amine), a series of group 12 metal complexes namely, [ZnLHCl][ZnLCl]·2HO (1), [CdL(SCN)(CHOH)] (2), and [Hg(l-pyCO)Cl] (3), were synthesized and structurally characterized. In all the complexes the piperazine nitrogen of the ligand takes part in coordination and leads to the complexes of group 12 metal ions having structural diversity. The X-ray diffraction analysis of complex 1 indicates for one Zn(ii) ion a geometry in between trigonal bipyramidal/square pyramidal and for the second a distorted tetrahedral sphere. In the polymeric complex 2 the Cd(ii) ion shows a distorted octahedral environment, while in the mononuclear complex 3, where Hg(ii) exhibits a square-pyramidal geometry, an unexpected condensation between the uncoordinated NH piperazine fragment with 2-pyridinecarboxaldehyde was detected. The M-N bond lengths in all the complexes are in accordance with the metal ionic radius. Continuous shape measures through a DFT approach provide the coordination environment around each metal centre that is comparable with the experimental observations. We have also investigated the importance of hydrogen bonding of methanol in the generation of the polymeric Cd complex 2 along with the rearrangement of the tridentate ligand to generate an octahedral complex. The photoluminescence properties of the complexes as well as of the ligand were investigated in solution at ambient temperature. The low quantum yield of the ligand was ascribed due to a very fast photoinduced electron transfer (PET) from the nitrogen lone pair to the conjugated pyridine moiety. Complexation prevents the electron transfer, and consequently an increase in quantum yield was observed in the complexes. Among the three complexes the highest photoluminescence was exhibited by a Zn complex, being lower in Cd and Hg complexes as a consequence of the heavy atom perturbation effect.

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Synthesis, Structures, and Antimicrobial Activity of Zinc and Copper Complexes Derived From N-isopropyl-N′-(1-pyridin-2-ylethylidene)ethane-1,2-diamine

Cited by 7 publications

References 26 publications

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

Synthesis, X-ray crystal structures and thermal analyses of some new antimicrobial zinc complexes: New configurations and nano-size structures

Group 12 metal complexes of (2-piperazine-1-yl-ethyl)-pyridin-2-yl-methylene-amine: rare participation of terminal piperazine N in coordination leads to structural diversity

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