Synthesis, structure, electrochemical properties, and antioxidant activities of copper(II) and zinc(II) complexes with <i>N,N</i>-bis(<i>N</i>-ethyl-2-ylmethylbenzimidazol)allylamine ligand

Shen, Kesheng; Han, Xintong; Li, Chuang; Huang, Guozhen; Mao, Shanshan; Shi, Xinkui; Wu, Huilu

doi:10.1080/00958972.2018.1454593

Cited by 23 publications

(2 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diverse geometry of these complexes and their ability to exchange ligands, combined with the therapeutic properties of metal ions and ligands, can lead to the synthesis of many new therapeutics with properties that are not found in the ligands alone. Zn complexes are known for their antimicrobial [ 23 , 24 , 25 , 26 , 27 , 28 ], anticancer [ 29 , 30 ], and antioxidant properties [ 24 , 30 , 31 , 32 , 33 , 34 , 35 ]. The therapeutic effects of drug–metal complexes are not only often comparable to those of conventional drugs, but they are also more active, selective, bioavailable, and have fewer side effects [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

et al. 2023

View full text Add to dashboard Cite

The ability of the indole–imidazole hybrid ligands to coordinate with the Zn(II) ion and the resulting structures of this new class of coordination compounds were analyzed in order to determine their structural properties and biological functionalities. For this purpose, six novel Zn(II) complexes, [Zn(InIm)2Cl2] (1), [Zn(InMeIm)2Cl2] (2), [Zn(IniPrIm)2Cl2] (3), [Zn(InEtMeIm)2Cl2] (4), [Zn(InPhIm)2Cl2] (5) and [Zn2(InBzIm)2Cl2] (6) (where InIm is 3-((1H-imidazol-1-yl)methyl)-1H-indole), were synthesized by the reactions of ZnCl2 and the corresponding ligand in a 1:2 molar ratio in methanol solvent at an ambient temperature. The structural and spectral characterization of these complexes was performed using NMR, FT–IR and ESI–MS spectrometry and elemental analysis, and the crystal structures of 1–5 were determined using single-crystal X-ray diffraction. Complexes 1–5 form polar supramolecular aggregates by utilizing, for this purpose, the N-H(indole)∙∙∙Cl(chloride) intermolecular hydrogen bonds. The assemblies thus formed differ depending on the distinctive molecular shape, which can be either compact or extended. All complexes were screened for their hemolytic, cytoprotective, antifungal, and antibacterial activities. The results show that the cytoprotective activity of the indole/imidazole ligand significantly increases upon its complexation with ZnCl2 up to a value comparable with the standard antioxidant Trolox, while the response of its substituted analogues is diverse and less pronounced.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Copper(II) complexes have been widely investigated in electrochemical studies because of their readily accessible oxidation states . Many studies have shown that the relevant electrochemical potentials play a marked role in determining the reactivity of copper(II) complexes mimicking redox (oxidase) enzymes …”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure, and antioxidative properties of a copper(II) complex with 1,2‐bis(benzimidazol‐2‐yl)ethane ligand

Tang

et al. 2019

J Chinese Chemical Soc

Self Cite

View full text Add to dashboard Cite

1,2-Bis(benzimidazol-2-yl)ethane (bbe) and its copper(II) complex, {[Cu(bbe) Br 2 ] 2 }Á2DMF (1), have been synthesized and characterized by elemental analysis, ultraviolet-visible, and infrared spectra. The single crystal structure analysis of 1 shows two crystallographically independent but chemically identical [Cu(bbe)Br 2 ] molecules. The coordination geometry of the copper atoms may best be described as a distorted tetrahedron (τ 4 = 0.740 for Cu1 and 0.696 for Cu2). The cyclic voltammogram of complex 1 represents quasi-reversible Cu 2+ /Cu + pairs. in vitro antioxidant tests showed that complex 1 has significant antioxidant activity against superoxide and hydroxy radicals. Photoluminescence investigations showed that the fluorescence intensity of complex 1 is significantly weaker than that of the ligand. This may be due to the paramagnetic effect of divalent copper to cause quenching of fluorescence. K E Y W O R D S 1,2-bis(benzimidazol-2-yl)ethane, antioxidant activity, copper(II) complex, crystal structure, electrochemistry, photophysical property

show abstract

Synthesis, crystal structure, redox property, and cytotoxic activity of a dinuclear cobalt(II) complex bearing a tetradentate benzimidazole ligand

Pan

Song

et al. 2019

Monatsh Chem

View full text Add to dashboard Cite

Synthesis, structure, electrochemical properties, and antioxidant activities of copper(II) and zinc(II) complexes with N,N-bis(N-ethyl-2-ylmethylbenzimidazol)allylamine ligand

Cited by 23 publications

References 75 publications

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

Synthesis, Structure and Biological Activity of Indole–Imidazole Complexes with ZnCl2: Can Coordination Enhance the Functionality of Bioactive Ligands?

Synthesis, structure, and antioxidative properties of a copper(II) complex with 1,2‐bis(benzimidazol‐2‐yl)ethane ligand

Synthesis, crystal structure, redox property, and cytotoxic activity of a dinuclear cobalt(II) complex bearing a tetradentate benzimidazole ligand

Contact Info

Product

Resources

About