Synthesis, structure characterization, spectral properties, DFT calculations, hirshfeld surface analysis, thermal stability and bioactivity of a new sulfamethoxazole zinc(II) complex

Habila, Imane; Bouchene, Rafika; Trifa, Chahrazed; Berrah, Fadila; Saoudi, Mouna; Benmerad, Belkacem; Boudraa, Mhamed; Mérazig, Hocine; Bouacida, Sofiane

doi:10.1016/j.molstruc.2022.132962

Cited by 3 publications

(1 citation statement)

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“…Control discs, containing DMSO, were employed. [27,28]. The cytotoxic activity using the conventional neutral red uptake assay of Pt(IV), Au(III) and Ru(III) cef complexes was evaluated against MCF-7 cells and HepG-2 cells [29].…”

Section: Antibacterial and Anticancer Testsmentioning

confidence: 99%

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

H. Alosaimi

2024

Bull. Chem. Soc. Eth.

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Three new metal complexes of ceftriaxone (cef), incorporating platinum(IV), gold(III), and ruthenium(III), were prepared. The complexes were prepared using a 1:2 molar ratio between ceftriaxone sodium salt (Na2cef) to AuCl3, PtCl4, and RuCl3 salts in methanol solvent. The as-synthesized complexes were characterized using microanalytical techniques for C, H, N, and S elements, magnetic and molar conductance measurements, as well as spectroscopic methods including FTIR, 1H NMR, and UV-Vis. The shape, morphology and size calculations have been examined using SEM, TEM, and X-ray diffraction data. The cef complexes were six-coordinate systems possessing a distorted octahedral geometry. Through the oxygen of both triazine and carboxylate moieties with the chemical formulae [Au(cef)2(Cl)(H2O)] (I), [Pt(cef)2(Cl)2] (II), and [Ru(cef)2(Cl)(H2O)] (III) the antibiotic cef acts as a bidentate ligand towards three metal ions. The newly created complexes demonstrated antibacterial activity showing efficacy in comparison to the cef sodium ligands. In vitro, antibacterial assays against specific microorganisms were evaluated to assess the antibacterial activities of the complexes. Cytotoxicity assays for cef complexes were conducted for HepG-2 and MCF-7 cell lines, representing human hepatocellular carcinoma and breast cancer, respectively. A value of 22.4 g and 26.2 g for 50% inhibitory concentration (IC50), respectively, for HepG-2 and MCF-7 were obtained for [Ru(cef)2(Cl)(H2O)] (III). KEY WORDS: Ceftriaxone sodium, Gold, Ruthenium, Platinum, Complexes, FTIR, IC50 Bull. Chem. Soc. Ethiop. 2024, 38(4), 937-948. DOI: https://dx.doi.org/10.4314/bcse.v38i4.10

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Section: Antibacterial and Anticancer Testsmentioning

confidence: 99%

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

H. Alosaimi

2024

Bull. Chem. Soc. Eth.

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Design and molecular docking studies of {N¹-[2-(amino)ethyl]ethane-1,2-diamine}-[tris(oxido)]-molybdenum(VI) complex as a potential antivirus drug: from synthesis to structure

Kumar

Choudhary

2023

Journal of Coordination Chemistry

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A New Copper Coordination 2d Polymer Based on Sulfanilamide Bidentate Ligand

Chebout

Boudraa

Habila

et al. 2023

Preprint

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Synthesis, structure characterization, spectral properties, DFT calculations, hirshfeld surface analysis, thermal stability and bioactivity of a new sulfamethoxazole zinc(II) complex

Cited by 3 publications

References 42 publications

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

Design and molecular docking studies of {N¹-[2-(amino)ethyl]ethane-1,2-diamine}-[tris(oxido)]-molybdenum(VI) complex as a potential antivirus drug: from synthesis to structure

A New Copper Coordination 2d Polymer Based on Sulfanilamide Bidentate Ligand

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Synthesis, structure characterization, spectral properties, DFT calculations, hirshfeld surface analysis, thermal stability and bioactivity of a new sulfamethoxazole zinc(II) complex

Cited by 3 publications

References 42 publications

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

Synthesis, spectroscopic, biological and structural characterizations for the gold(III), platinum(IV), and Ruthenium(III) ceftriaxone drug complexes

Design and molecular docking studies of {N1-[2-(amino)ethyl]ethane-1,2-diamine}-[tris(oxido)]-molybdenum(VI) complex as a potential antivirus drug: from synthesis to structure

A New Copper Coordination 2d Polymer Based on Sulfanilamide Bidentate Ligand

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Product

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Design and molecular docking studies of {N¹-[2-(amino)ethyl]ethane-1,2-diamine}-[tris(oxido)]-molybdenum(VI) complex as a potential antivirus drug: from synthesis to structure