Synthesis, structure and redox potentials of biologically active ferrocenylalkyl azoles

Ferrocenylalkyl azoles: bioactivity, synthesis, structure

“…[8,25,28,29] Using this method, we prepared a variety of neutral ferrocene-containing benzotriazoles, fluoro-containing benzimidazoles and diferrocenyl-substituted salt of benzotriazole. Some of these have been prepared for in vivo experiments ( Fig.…”

“…Compounds 1 ( (6) and 1.481(5)´Å] are somewhat longer than in ferrocenylmethyl imidazole (1.474´Å) [8] and ferrocenylmethyl benzimidazole (1.450´Å). [8] swinging group, a structural adjustment lipophilic fragment, penetration through membrane (1).…”

“…[8] swinging group, a structural adjustment lipophilic fragment, penetration through membrane (1). Possible transportation routes and interactions in the cell [27] (reproduced with permission from Russ.…”

“…Ferricenium salts belong to the medium toxicity series. [3] Preliminary in vitro investigations showed the low cytotoxicity of such types of ferrocene compounds as benzimidazolium and benzotriazolium bis-ferrocene-containing salts (8), ferricenium and symm.-diethylferricenium triiodides (9,10), and ferrocenylenemethylene oligomer. [2] As we have found, for ferrocenylalkyl azoles, a pronounced decrease in toxicity is observed as compared with the toxicity of ferrocene (even by 1.5-4 times).…”

Synthesis of Ferrocene-Modified Porphyrins by Reductive Amination Reaction

“…[3] Ferrocenyl heterocyclic compounds have been found to exhibit biological activities (e.g. antitumor [4] and antimicrobial [5] ). Noteworthy, pyrazole motif makes up the core structure of numerous biologically active compounds.…”