2-Guanidinobenzimidazole (GBI) derivatives with a NHR group in place of NH 2 (R: a, CH 2 Ph; b, (S C )-CH(CH 3 )Ph; c, (R C R C )-CH(CH 2 ) 4 CHNMe 2 ; d, (R C R C )-CH-(CH 2 ) 4 CH-NCH 2 (CH 2 ) 3 CH 2 ) are prepared in four steps from 2-aminobenzimidazole. Reactions with [(η 5 -C 5 H 5 )Ru(CO)-(NCCH 3 ) 2 ] + PF 6 − (5 + PF 6 − ) afford the chiral-at-metal chelates [(η 5 -C 5 H 5 )Ru(CO)(GBI-R)] + PF 6 − (6a−d + PF 6 − , 39−77%), which have been characterized by NMR ( 1 H, 13 C, 31 P, 19 F) and other spectroscopy. The Ru,C configurational diastereomers of the dimethylamino containing complex 6c + PF 6 − separate upon alumina chromatography (R Ru R C R C , >99:01 dr; S Ru R C R C , <2:98 dr) but slowly epimerize at ruthenium in solution at room temperature. Configurations have been assigned by CD spectra and the crystal structure of (R Ru R C R C )-6c + (Δ)-TRISPHAT − (TRISPHAT − = P(o-C 6 Cl 4 O 2 ) 3 − ). The latter reveals hydrogen bonding between two of the GBI-R NH linkages and the TRISPHAT oxygen atoms. Both diastereomers catalyze (10 mol %, room temperature) additions of malonate esters to nitroalkenes in high yields and enantioselectivities (90−99% ee for aryl-substituted nitroalkenes). The dominant product configurations are identical, showing the chiral ruthenium center to have little influence. The free GBI-R ligand exhibits only modest activity. Unlike most transition-metal-catalyzed reactions, there is no direct interaction of the substrate with the ruthenium; rather, evidence is presented for "second coordination sphere promoted catalysis" mediated by hydrogen bonds derived from two NH groups that chelation preorganizes in a synperiplanar conformation.