Synthesis, structure, and DNA-binding properties of manganese(II) and zinc(II) complexes with tris(N-methylbenzimidazol-2-ylmethyl)amine ligand

Abstract

Tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its two complexes, [Mn(Mentb)(DMF)-(H 2 O)](pic) 2 1 and [Zn(Mentb)(pic)](pic) 2 (pic = picrate), have been synthesized and characterized by physico-chemical and spectroscopic methods. Single crystal X-ray diffraction revealed that the two complexes have different structures. In complex 1, the coordination sphere around Mn(II) is distorted octahedral, whereas in complex 2 the coordination sphere around Zn(II) is distorted trigonal bipyramidal. The DNA-binding properties of the free ligand and its two complexes have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that the ligand and its two complexes bind to DNA via an intercalation binding mode, and their binding affinity for DNA follows the order 1 [ 2 [ ligand.

Synthesis, structure, DNA-binding properties, and antioxidant activity of copper(II) and cobalt(II) complexes with bis(N-allylbenzimidazol-2-ylmethyl)benzylamine

“…These bands are assigned to p ? p* (imidazole) transitions [12]. Conversely, the bands are marginally blue-shifted (5-6 nm) for complex 2, this phenomenon also shows that C=N is involved in coordination to the metal center [40].…”

“…In previous studies [11][12][13][14], we have investigated that the coordinating ability of various benzimidazole ligands. In this study, the synthesis, characterization, and DNA-binding activities of two transition metal complexes with bis(Nallylbenzimidazol-2-ylmethyl)benzylamine are presented.…”

Bioattenuation of phenol and cyanide involving immobilised spent tea activated carbon with Alcaligenes faecalis JF339228: Critical assessment of the degraded intermediates

“…Thus, a deflation in the fluorescence intensity of the EB‐DNA is caused by the intercalation of the second molecule into DNA. The expanse of fluorescence quenching of EB dye cohered to hs‐DNA is mainly due to the competitive binding of EB with the second molecule . The fluorescence excitation and emission spectra published by Molecular Probe EB‐hs DNA complex is represented in Figure a.…”

A Schiff base ligand N-(2-hydroxylacetophenone)-3-oxapentane-1,5-diamine and its nickel(II) complex: synthesis, crystal structure, antioxidation, and DNA-binding properties

“…4, the K SV values of compound are (1.7 ± 0.105) 9 10 3 M -1 (R 2 = 0.952 for 16 points) and (7.0 ± 0.097) 9 10 3 M -1 (R 2 = 0.974 for 16 points) for HL and the complex, respectively. These values show that both the free ligand and complex can compete for DNAbinding sites and so displace EB from the DNA, which is usually characteristic of the intercalative interaction of compounds with DNA [46]. Moreover, the binding strength of the complex is greater than that of the free ligand [46].…”