Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide

Bjelogrlić, Snežana K.; Todorović, Tamara R.; Bacchi, Alessia; Zec, Manja; Sladić, Dušan; Srdiċ-Rajiċ, Tatjana; Radanović, Dušanka; Radulović, Siniša; Pelizzi, Giancarlo; Anđelković, Katarina

doi:10.1016/j.jinorgbio.2010.02.009

Cited by 57 publications

(53 citation statements)

References 45 publications

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“…Cadmium complexes have attracted more and more attentions because of their widely reported bioactivities, such as DNA binding affinity [17] and antibacterial activities [18]. Meanwhile, the antitumor activities of cadmium(II) complexes have been reported more frequently [19,20], despite the metal was regarded as a human carcinogen. Previous chemists reported that complexation of the cadmium ions could enhance their anticancer behaviors, and the cadmium complexes possessed the moderate cytotoxic activities [21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

Warad

Abdoh

Naveen

et al. 2015

Journal of Molecular Structure

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

Warad

Abdoh

Naveen

et al. 2015

Journal of Molecular Structure

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“…Selenosemicarbazones, in which the sulfur atom is substituted by the selenium atom, also showed potential anti-tumor activity [15, 16, 25–28]. Herein, we report that a novel selenosemicarbazone copper complex (2-24a/Cu) can efficiently inhibit cancer cell proliferation and induce cancer cell death, and can serve as the basis for designing other novel anti-cancer selenosemicarbazone compounds.…”

Section: Discussionmentioning

confidence: 99%

A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells

et al. 2014

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BackgroundThe 90-kDa heat shock protein HSP90AA1 is critical for the stability of several proteins that are important for tumor progression and thus, is a promising target for cancer therapy. Selenosemicarbazone metal complexes have been shown to possess anticancer activity through an unknown molecular mechanism.MethodsThe MTT assay, fluorescence-activated cell sorting, and fluorescent microscopy were used to analyze the mechanism of the anti-cancer activity of the selenosemicarbazone metal complexes. Additionally, RNA-seq was applied to identify transcriptional gene changes, and in turn, the signaling pathways involved in the process of 2-24a/Cu-induced cell death. Last, the expression of HSP90AA1, HSPA1A, PIM1, and AKT proteins in 2-24a/Cu-treated cells were investigated by western blot analysis.ResultsA novel selenosemicarbazone copper complex (2-24a/Cu) efficiently induced G2/M arrest and was cytotoxic in cancer cells. 2-24a/Cu significantly induced oxidative stress in cancer cells. Interestingly, although RNA-seq revealed that the transcription of HSP90AA1 was increased in 2-24a/Cu-treated cells, western blotting showed that the expression of HSP90AA1 protein was significantly decreased in these cells. Furthermore, down-regulation of HSP90AA1 led to the degradation of its client proteins (PIM1 and AKT1), which are also cancer therapy targets.ConclusionOur results showed that 2-24a/Cu efficiently generates oxidative stress and down-regulates HSP90AA1 and its client proteins (PIM1, AKT1) in U2os and HeLa cells. These results demonstrate the potential application of this novel copper complex in cancer therapy.

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“…The complex of thiosemicarbazones shows a number of medicinal properties. They also have antitubercular activity 1 . Its complex is active against viruses, influenza, protozoa, small pox 2 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterisation and Biological Activity of Vanadium (V) With 2,4-Dihydroxy Cinnamaldehyde Thiosemicarbazone (2,4-Dctsc)

Borhade¹

2017

Int. Res. J. Pharm.

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The 2,4-Dihydroxy cinnamaldehyde thiosemicarbazide has been synthesized. Complex of 2,4-dihydroxy cinnamaldehyde thiosemicarbazide with transition metals, Vanadium (v) has been synthesized in methanol medium. The formation of the complex are endothermic processes. The ligand was characterized by melting point, elemental analysis, absorption spectra and antimicrobial activity while the complex was chara cterized by melting point, absorption spectra, A simple and sensitive spectrophotometric method was developed for transition metal complex of 2,4-dihydroxy cinnamaldehyde thiosemicarbazide. The optimum condition for complete colour development have been established. The stability constant, dissociation constant & change in free energy of vanadium (v) has been determined by Job's variation & mole ratio method indicate that the M:L is 2:1 . Tolerance limit of diverse ions in the determination of vanadium (v) with is investigated. Antimicrbial activity and antifungal activity have been studied.

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Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide

Cited by 57 publications

References 45 publications

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells

Synthesis, Characterisation and Biological Activity of Vanadium (V) With 2,4-Dihydroxy Cinnamaldehyde Thiosemicarbazone (2,4-Dctsc)

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