Synthesis, structure and characterization of adenine-based aminocarbene complexes of platinum(II)

Activation of Acetyl Ligands through Hydrogen Bonds: A New Way to Platinum(II) Complexes Bearing Protonated Iminoacetyl Ligands

“…The N3···O2 distances (2.636(5) Å, 6a ; 2.646(5) Å, 6b ; 2.65(1) Å, 6e ) indicate moderate hydrogen bonds . The C3N3 bond lengths (1.294(5)–1.31(1) Å) are at the lower end of the range of other platinum(II) complexes bearing protonated iminoacyl ligands in which the N H protons are not involved in hydrogen bonds (1.31(1)–1.346(5) Å; n = 6 , ), but longer than those in platinum complexes bearing (nonprotonated) iminoacyl ligands (median 1.276 Å; lower/upper quartile 1.261/1.288 Å; n = 14). Furthermore, the deprotonation of the oxime ligands gives rise to a strong shortening of the N1–O2 bonds (1.31(1)–1.328(4) Å) in comparison to the respective bonds both in type 4 complexes (1.360(4)–1.368(4) Å) and in platinum(II) complexes with (neutral) oxime ligands that are not involved in hydrogen bonds (median 1.393 Å; lower/upper quartile 1.385/1.408 Å; n = 27).…”

“…Another way to activate acyl ligands for Schiff-base type reactions proved to be the protonation as exemplified with acyl tin compounds . The activation of acetyl ligands discussed here should not be confused with reactions of metalla-β-diketones (i.e., hydrogen-bridged hydroxycarbene–acyl complexes) with amines, resulting in metalla-β-ketoimines, which proceed at the hydroxycarbene ligand. , …”

Not the usual suspect – an unexpected organometallic product during the synthesis of cytotoxic platinum(ii) complexes

“…20,21 Furthermore, complexes with up to two coordinating nitrogen atoms and at least one coordinating carbon atom are known as well. 22–30…”

“…Furthermore, complexes with up to two coordinating nitrogen atoms and at least one coordinating carbon atom are known as well. [22][23][24][25][26][27][28][29][30] With the aim of learning more about the cytotoxic properties of this type of organometallic platinum(II) complex, we additionally synthesized a small series of close derivatives with increasing lipophilicity (complexes 3b-3f, Scheme 2). The target complexes were fully characterized by one-and twodimensional multinuclear ( 1 H, 13 C, 15 N, 195 Pt) NMR spectroscopy and high-resolution mass spectrometry and were investigated with respect to their cytotoxic properties in three human cancer cell lines and for their impact on the DNA secondary structure in a cell-free assay.…”

Platinum-Catalyzed Hydrative Dimerization of Alkynylsilanes to α,β-Unsaturated Ketones

“…10 When the PtCl 2 -catalyzed reaction of 1p with water was conducted in the absence of CuCl and LiCl, a white precipitate ( 9) was formed along with a small amount of 2p (21% yield). 1 H and 13 C NMR spectra of 9 showed the presence of a cyclohexylacetyl group, and a broad proton signal appeared at 18.4 ppm. When 9 was recrystallized from hexane, a needle crystal was obtained.…”