Synthesis, structure and catalytic activity of novel five-membered Pd(II) and Pt(II) metallaheterocycles based on 1,2-bis(3,5-dimethylisoxazol-4-yl-methylsulfanyl)ethane

Akhmadiev, Nail S.; Mescheryakova, Ekaterina S.; Khisamutdinov, R. A.; Лобов, А. Н.; Абдуллин, М. И.; Ибрагимов, А. Г.; Кунакова, Р. В.

doi:10.1016/j.jorganchem.2018.07.026

Cited by 4 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Сis -S,S-dichloride-1,6-(3,5-dimethylisoxazol-4-yl)-2,5-dithiahexane palladium(II) – compound II has been synthesized according to a published procedure. 24 The characteristics of palladacycle II has been identical to the literature data. 24…”

Section: Methodssupporting

confidence: 73%

See 1 more Smart Citation

Molecular Docking and Preclinical Study of Five-MemberedS,S-Palladaheterocycle as Hepatoprotective Agent

et al. 2019

View full text Add to dashboard Cite

Purpose: In order to investigate mechanisms underlying the hepatoprotective action of S,Spalladaheterocycle, inhibition of cytochromes P450 has been modeled by molecular docking of four palladaheterocycle stereoisomers to the active sites of an enzymatic oxidase system. To obtain a deeper insight into biochemical aspects providing a basis for the therapeutic effects of five-membered palladacycles (as mixture of stereoisomers), a number of preclinical trials has been conducted Methods: 2D and 3D structures of palladaheterocycle stereoisomers were obtained via converting into SDF files by means of software MarvinSketch. Binding of palladaheterocycle at the active sites of cytochromes P450 2E1 and P450 2C9 has been studied by molecular docking using LeadIT 2.3.2. Hepatoprotective activity of palladaheterocycle at 2.5, 25 and 250 mg/kg doses has been studied based on a model of acute intoxication by CCl4 using in vivo methods. Results: By molecular docking it was identify amino acid fragments responsible for binding with palladacyclic isomers. The tested compound is comparable, in terms of its activity to the hepatoprotective drug SAM according to the in vivo and in vitro experiments such as animal survival data, the efficiency of correction of the cytolytic syndrome, the liver excretory function, carbohydrate, protein and lipid metabolism, and the correction efficiency of the liver antitoxic function (the latter has been determined based on the results of a hexobarbital control experiment). Conclusion: Taking into account results obtained in vivo, in vitro and in silico, it can be concluded that the five-membered S,S-palladaheterocycle effectively protect the liver against acute damage caused by CCl4 , via activation of catalase and glucuronyltransferase, as well as via inhibition of the oxidative stress enzymes.

show abstract

Section: Methodssupporting

confidence: 73%

“…Reaction rate constants for the conversion between anti - IIa and syn - IIa were equal to 9.0 s -1 (293 K), 20.2 s -1 (303 K). 24…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking and Preclinical Study of Five-MemberedS,S-Palladaheterocycle as Hepatoprotective Agent

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Palladium and platinum N,N 0 -complexes were prepared by mixing sulfanyl-substituted pyrazole ligands with metal salts (PdCl 2 , PdBr 2 , K 2 PtCl 4 ) in a 2 : 1 ratio at room temperature in acetonitrile or aqueous acetone using general procedures described previously. 27 The isolated compounds were air-stable powders, readily soluble in DMSO and DMF and insoluble in water, ethers or chlorinated solvents (Scheme 2).…”

Section: Chemistrymentioning

confidence: 99%

Synthesis of newN,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of theirin vitroanticancer activity

et al. 2020

View full text Add to dashboard Cite

show abstract

Synthesis and Biological Evaluation of 1,3,5-Dithiazinanes: Synthesis, Stereochemistry and Applications

Akhmetova,

Akhmadiev

2024

S-Heterocycles

View full text Add to dashboard Cite

Synthesis, structure and catalytic activity of novel five-membered Pd(II) and Pt(II) metallaheterocycles based on 1,2-bis(3,5-dimethylisoxazol-4-yl-methylsulfanyl)ethane

Cited by 4 publications

References 35 publications

Molecular Docking and Preclinical Study of Five-MemberedS,S-Palladaheterocycle as Hepatoprotective Agent

Molecular Docking and Preclinical Study of Five-MemberedS,S-Palladaheterocycle as Hepatoprotective Agent

Synthesis of newN,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of theirin vitroanticancer activity

Synthesis and Biological Evaluation of 1,3,5-Dithiazinanes: Synthesis, Stereochemistry and Applications

Contact Info

Product

Resources

About