Synthesis, structure, and BSA binding studies of a new Co(II) complex based on 2-(1H-tetrazol-1-methyl)-1H-imidazole-4,5-dicarboxylic acid

Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities

“…Investigating the literature, three (5) were reported [22][23][24]. Further study showed that their structures and the coordination modes of the H 3 tmidcderived anions are different from complexes 1 and 2.…”

“…K sv , K q , K b , n values, and thermodynamic parameters for complex-HAS systems at three different temperatures. In the three reported H 3 tmidc-based complexes [22][23][24], researchers investigated the BSAbinding properties of complexes [Co(Htmidc)(H 2 O) 2 ] n (3) and [Cd 2 (H 2 tmidc) 4 (H 2 O) 2 ]•6H 2 O (4). Further study showed that the Stern-Volmer quenching constants (K sv ) of complex 1 are slightly smaller than those of complexes 3 and 4, but the K sv values of complex 2 are slightly larger than those of complexes 3 and 4 [22,23].…”

“…In the three reported H 3 tmidc-based complexes [22][23][24], researchers investigated the BSAbinding properties of complexes [Co(Htmidc)(H 2 O) 2 ] n (3) and [Cd 2 (H 2 tmidc) 4 (H 2 O) 2 ]•6H 2 O (4). Further study showed that the Stern-Volmer quenching constants (K sv ) of complex 1 are slightly smaller than those of complexes 3 and 4, but the K sv values of complex 2 are slightly larger than those of complexes 3 and 4 [22,23]. These indicate that complex 1 exhibits a lower BSA quenching ability than complexes 3 and 4, while complex 2 displays higher BSA quenching ability than complexes 3 and 4.…”

“…Imidazole compounds, such as lansoprazole, ( R )-omeprazole, pantoprazole are suitable for the treatment of gastric ulcer, duodenal ulcer, reflux esophagitis; miconazole is a highly effective and safe broad-spectrum antifungal agent, which has effects on almost all pathogenic fungi. In addition, researchers have synthesized many imidazole and tetrazole derivatives, as well as their corresponding complexes, and investigated their structures, BSA/HAS binding abilities, and antitumor activities [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. For example, Cu(II) complexes [Cu(phen)(L) 2 ] and [Cu(dmphen)(L) 2 ] (HL = 5-benzyl-tetrazole, phen = 1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline) demonstrated the highest cytotoxicity against Hep2, HepG2, and MCF-7 [ 13 ].…”

Crystal structure of catena-poly[triqua-bis(μ 2-4-carboxy-2-(1H-tetrazol-1-yl)-1H-imidazole-5-carboxylato-k3 N,O:O′)barium(II)] tetrahydrate, C14H14BaN12O15

“…The N-heterocyclic carboxylic acid, 2-(1Htetrazol-1-methyl)-1H-imidazole-4,5-dicarboxylic acid and the deprotonated anions are excellent ligands as there are potential N-donors and O-donors. Researchers have reported two transition metal complexes based on H 3 tmidc and investigated their crystal structures and biological activities [11,12]. In order to further enrich the number of complexes based on this ligand, we selected H 3 (14) Å, all of which are comparable to those observed for the other Ba(II) complexes based on N-heterocyclic carboxylic acids [13,14].…”