Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors

Mirzaei, Salimeh; Hadizadeh, Farzin; Eisvand, Farhad; Mosaffa, Fatemeh; Ghodsi, Razieh

doi:10.1016/j.molstruc.2019.127310

Cited by 59 publications

(27 citation statements)

References 40 publications

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“…In case of K562 cells, 2-methylquinoline 85 (Figure 8) bearing 2-methoxyphenol through 2-methylpropanone fragment has exhibited spectacular activity (IC 50 = 9 nM) and is found to be higher compared to CA The facts on tubulin inhibitors inspired to design chalcones of quinoline-tetrazole derivatives. [103] Compared to CA-4, except for two derivatives, poor antiproliferative potencies are observed for screened derivatives. 3,4,5-Trimethoxy group-tethered 8-benzoyl-2-chloroquinoline 86 (Figure 8) is reported to be topmost inhibitor against growth of cell lines A2780, A2780RCIS, MCF-7, MCFMX, and HUVEX.…”

Section: Chalcone-containing Quinoline Derivativesmentioning

confidence: 96%

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Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Dorababu¹

2020

ChemistrySelect

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Quinoline has been a most essential pharmacophore, derivatization of which led to enticing pharmacological properties. Quinoline is responsible for a wide range of biological potencies such as antibacterial, antifungal, anti-leishmanial, antimalarial, antioxidant and anticancer properties. Out of these clinical importances, the anticancer property of heterocycles is of greatest concern as cancer has become a major threat globally. Since some natural products containing quinoline moiety have displayed cancer inhibition potency, quinoline has been given highest priority in the anticancer drug design and development. In addition, quinoline has got eight positions including nitrogen for substitution which may result in some potential anticancer properties. Ever since, this extraordinary potential is being utilized in anticancer drug discovery. In this review, the various trends in drug design of quinoline moiety anticipating finest anticancer properties through cancer cell growth inhibition are collated comprehensively. The review work is classified based on type of quinoline derivatives. Besides this, with the aid of structure-activity relationship discussion, the importance of structural units that contributed to strongest activity towards cancer inhibition is emphasized. The particular activity would help to bring further advanced anticancer agents in the future.

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Section: Chalcone-containing Quinoline Derivativesmentioning

confidence: 96%

“…Structures of quinoline-chalcone analogs exerting potent anticancer activity [100][101][102][103][104]. …”

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confidence: 99%

Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Dorababu¹

2020

ChemistrySelect

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“…Mirzaei et al [138] synthesized and evaluated a series of quinoline-chalcone hybrids to discover a promising tubulin inhibitors and anticancer activity. Among all docking studies of compound 18 into the colchicine binding site of tubulin showed the possible interaction with the active site of tubulin (fig.…”

Section: Topoisomerase (Topo) Inhibitorsmentioning

confidence: 99%

Pyridine Moiety: Recent Advances in Cancer Treatment

Sahu¹,

Mishra²,

Kumar³

et al. 2021

ijps

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Pyridine is an imperative pharmacophore, a privileged scaffold and an exceptional heterocyclic system in the field of drug discovery which provides many opportunities in study/explore this moiety as an anticancer agent by acting on various receptors of utmost importance. Several pyridine derivatives are reported to inhibit tubulin polymerization, androgen receptors, human carbonic anhydrase, kinase, topoisomerase enzyme and many other targets for controlling and curing global health issue of cancer. Now a days in combination with other moieties researchers are focusing for development of pyridine new entities for the treatment of cancer. This review throws light on recent biological expansions of pyridine along with their structure activity relationships/molecular docking to deliver association between various synthesized newer derivatives and receptor sites.

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“…SAR indicated that the benzoyl group at C-8 and C-6 of quinoline moiety and R 1 ' = R 2 ' = R 3 ' = OMe were found to enhance the activity (Scheme 19). [79]…”

Section: Quinoline-chalcone Hybridsmentioning

confidence: 99%

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Panda

Chakroborty

2020

ChemistrySelect

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The emergence of drug resistance and low specificity with side effects are the significant challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this is an imperative prerequisite to develop novel anticancer agents through mainstream medicinal chemistry approaches. The intriguing quinoline and its derivatives have demonstrated as significant building blocks for the locating of new promising anticancer agents. Consequently, quinoline moiety with the addition of suitable congeners would offer a strategy for the development of potential drug candidates. This present review article summarizes the recent advances (2018‐2020) of quinoline hybrids and their anticancer activity. The mechanism action and plausible structure‐activity relationship have discussed.

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Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors

Cited by 59 publications

References 40 publications

Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Report on Recently (2017–20) Designed Quinoline‐Based Human Cancer Cell Growth Inhibitors

Pyridine Moiety: Recent Advances in Cancer Treatment

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

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