Synthesis, Structural Investigations, and In Vitro/In Silico Bioactivities of Flavonoid Substituted Biguanide: A Novel Schiff Base and Its Diorganotin (IV) Complexes

Abstract

Quercetin is one of the most powerful bioactive dietary flavonoids. The in vivo biological study of quercetin is extremely difficult due to its very low solubility. However, diorganotin complexes of quercetin are more useful when contrasted with quercetin due to increased solubility. In the present study, quercetin, substituted biguanide synthesized in the form of Schiff base and its di-alkyl/aryl tin (IV) complexes were obtained by condensing Schiff base with respective di-alkyl/aryl tin (IV) dichloride. Advanced analytical techniques were used for structural elucidation. The results of biological screening against Gram-positive/Gram-negative bacteria and fungi showed that these diorganotin (IV) derivatives act as potent antimicrobial agents. The in silico investigation with dihydropteroate (DHPS) disclosed a large ligand–receptor interaction and revealed a strong relationship between the natural exercises and computational molecular docking results.

Organotin complexes with Schiff’s base ligands: insights into their cytotoxic effects on lung cancer cells

“…Several studies have been done to study the cytotoxic properties of organotin(IV) complexes against various cancer cell lines [16,17]. For example, a research done by Abbas et al (2022) reported the synthesis of novel organotin(IV) complexes with Schiff base ligands and evaluated their cytotoxicity in vitro in silico bioactivities [18]. The results demonstrated a cytotoxic effects and emphasized the potential of these complexes as anti-cancer agents.…”