Synthesis, structural investigations, and cytotoxic evaluation of a half‐sandwich Ru(II)‐arene complex

Abstract

We report the design, synthesis, and cytotoxic evaluation of a new organoruthenium(II) complex (1). Complex 1 was characterized by analytical and spectroscopic methods including single crystal X‐ray diffraction studies. Complex 1 crystallized in an orthorhombic crystal system with Pca21 space group with Ru(II) ion p‐cymene arene unit in a usual “piano‐stool” geometry. The DFT and TDFT studies were carried out to provide better insight about the spectral properties of the complex. The Hirshfeld surface analysis plots revealed significant intermolecular interactions within the crystal structure that essentially involve a network of N–H···H, O–H···O, and C–H···O linkages. DNA photocleavage activity revealed oxidative mechanistic pathway with preferential affinity toward minor groove. Cytotoxic studies of complex 1 via SRB assay revealed moderate but selective activity toward pancreatic and cervical cancer cell lines.

Synthesis, structure, properties, and cytotoxicity of a (quinoline)RuCp+ complex

“…6–8 Notably, in the context of this work, many η 5 -cyclopentadienyl and η 6 -arene complexes have shown promising biological activities. 5–19…”

“…[6][7][8] Notably, in the context of this work, many η 5 -cyclopentadienyl and η 6 -arene complexes have shown promising biological activities. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Many ruthenium complexes are known to exhibit biological activities, and ruthenium(II) forms many stable cationic arene complexes. [20][21][22][23] We decided to use a CpRu + fragment for this study as it is readily accessible, forms stable arene complexes, and has derivatives that are known to inhibit cancer cell proliferation.…”

NiIIand CoIIbinary and ternary complexes of 3-formylchromone: spectroscopic characterization, antimicrobial activities, docking and modeling studies

“…4 The two electrophilic sites (C1 and C4) may react with bis-nucleophilic reagents, such as enamine ketones/esters, heterocyclic ketene aminals (HKAs), or 1,1-enediamine (EDAMs) 4 among others, 4 to produce the site-selective synthesis of fused heterocycles. Because it comprises a wide range of pharmacologically active chemicals, such as antimicrobial, anti-inflammatory, antiallergic, anti-HIV, antitumor, antiplaque, antioxidant and neuroprotective, 5–9 as well as acting as a fluorescent marker, the bicyclic chromone moiety has been categorized as a favorable structure in drug discovery. 2 Protein kinases P13Ks, CDK, and TNF signaling, among other cancer targets, are known to be inhibited by chromone derivatives.…”