Synthesis, structural investigation, DNA and protein binding study of some 3d-metal complexes with N′-(phenyl-pyridin-2-yl-methylene)-thiophene-2-carboxylic acid hydrazide

Mishra, Mansi; Tiwari, Karishma; Shukla, Sachin; Mishra, Rakesh K.; Singh, Vinod P.

doi:10.1016/j.saa.2014.05.007

Cited by 53 publications

(18 citation statements)

References 49 publications

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“…The fluorescence of BSA is due to intrinsic characteristics of tyrosine and tryptophan residues [40]. In general, changes in the emission spectra of tryptophan are common in response to protein conformational transitions, subunit associations, or denaturation.…”

Section: Fluorescence Quenching Of Bsamentioning

confidence: 99%

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Yan

Chang

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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Section: Fluorescence Quenching Of Bsamentioning

confidence: 99%

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Yan

Chang

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…Hydrolases play an important role in the biochemical processes, which can catalyze the hydrolysis of various compounds like carboxylic esters, phosphoesters, amides, nucleic acids, and peptides. The design of artificial hydrolases leads to vast application prospects in many aspects, e.g., molecular genetic tools, the degradation of toxic phosphate esters, the design of medicine, and functional materials [59][60][61][62]. Recent reports present metal complexes such as Cu 2+ , Co 2+ , Ni 2+ , Zn 2+ with macrocycles having in its molecule nitrogen and oxygen atoms behave perfectly as an artificial hydrolase.…”

Section: Scheme 2 Investigated Ligand Lmentioning

confidence: 99%

Mass Spectrometry Reveals Complexing Properties of Modified PNP-Lariat Ether Containing Benzyl Derivative of (S)–Prolinamine

et al. 2019

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In the investigation presented here the synthesis of new lariat ether derivative obtained from the modification of tetrapyrrolidinyl-PNP-crown ether macrocycle is described. The polyheterotopic molecular coreceptor consisted of the replacement of chlorine atoms with an optically active (S)-(1-benzylpyrrolidin-2-yl) methanamine. The structure was confirmed by using elemental analysis, mass spectrometry, and NMR spectroscopy. This work covers results concerning the complexing properties of the new ligand towards Ag + , Cu 2+, Co 2+, Ni 2+ , and Zn 2+ ions. The formation of non-covalent complexes of 1:1 stoichiometry with the Cu 2+, Co 2+, Ni 2+ , and Zn 2+ ions have been confirmed by mass spectrometry. Due to the previous work and application possibilities, a large emphasis was put on the investigation of the complexation ability of lariat ether with silver (I) cation to determine stability constants by direct potentiometric method. In this case, the formation of four different forms of complexes AgL, Ag 2 L, Ag 3 L, and Ag 4 L has been proved. The observed unusual binding through the nitrogen atoms from the exocyclic substituents may provide the structural unit to build a new coordination polymers.Molecules 2020, 25, 136 2 of 19 the preparation of the number of crown ethers, which can be used in various applications such as classical (polymer-supported catalysts PTC, reagents for separation and extraction, etc.) and highly sophisticated (the redox switches for membrane transport, synthetic cation-conducting channels, nucleotide-based molecular boxes and enzyme mimics) [7][8][9][10][11][12]. There are three known main types of lariat ethers: C-pivot lariat ethers [13][14][15], where the side arm is attached to the carbon atom, N-pivot lariat ethers [16][17][18], and finally P-pivot lariat ethers [19,20].The subjects of this research are the P-pivot lariat ether derivatives. The versatile precursors for this type of P-pivot lariat ethers have been obtained by the reaction of hexachlorocyclotriphosphazene with tetraethylene glycol in the presence of sodium hydride (Scheme 1).Molecules 2019, 24, x 2 of 19 various applications such as classical (polymer-supported catalysts PTC, reagents for separation and extraction, etc.) and highly sophisticated (the redox switches for membrane transport, synthetic cation-conducting channels, nucleotide-based molecular boxes and enzyme mimics) [7][8][9][10][11][12]. There are three known main types of lariat ethers: C-pivot lariat ethers [13][14][15], where the side arm is attached to the carbon atom, N-pivot lariat ethers [16][17][18], and finally P-pivot lariat ethers [19,20]. The subjects of this research are the P-pivot lariat ether derivatives. The versatile precursors for this type of P-pivot lariat ethers have been obtained by the reaction of hexachlorocyclotriphosphazene with tetraethylene glycol in the presence of sodium hydride (Scheme 1). Scheme 1. Formation of different types of macrocyclic compounds from hexachlorocyclotriphosphazene substrate. Scheme 1. Formation of dif...

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“…The field of coordination chemistry of transition metal complexes with Schiff base ligands is an important and captivating area of chemistry. Schiff base molecules afford potential sites for bio‐chemically active compounds that are related to intermolecular hydrogen bonding and proton transfer equilibria . Metal complexes of Schiff base ligands possess a variety of applications in the biological, analytical, clinical, and industrial areas .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral and antibacterial activity of Co(II), Ni(II) and Zn(II) complexes with 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H‐naphthalen‐1‐ylidene)‐hydrazide

Tyagi

Chandra

2017

Applied Organom Chemis

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A bioactive Schiff base HL i.e. 2-hydroxy-benzoic acid(3,4-dihydro-2Hnaphthalen-1-ylidene)-hydrazide was synthesized by reacting equimolar amount of salicylic acid hydrazide and 1-tetralone. Co(II), Ni(II) and Zn(II) complexes of ligand HL was synthesized in 1:1 and 1:2 molar ratio of metal to ligand. The structure of the synthesized ligand and metal complexes was established by elemental analysis, molar conductance, magnetic susceptibility measurements, electronic, IR and EPR spectral techniques. For determining the thermal stability the TGA has been done. In DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31 + g(d,p) basis set. Spectral data reveal that ligand behave uninegative tridentate in ML complexes and uninegative bidentate in ML 2 complexes. On the basis of characterization octahedral geometry has been assigned for Co(II) and Ni(II) complexes, while tetrahedral for Zn(II) complexes. Antibacterial activity of the synthesized compounds were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Xanthomonas campestris and Pseudomonas aeruginosa and the results revealed that metal complexes show enhanced activity in comparison to free ligand.

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Synthesis, structural investigation, DNA and protein binding study of some 3d-metal complexes with N′-(phenyl-pyridin-2-yl-methylene)-thiophene-2-carboxylic acid hydrazide

Cited by 53 publications

References 49 publications

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Mass Spectrometry Reveals Complexing Properties of Modified PNP-Lariat Ether Containing Benzyl Derivative of (S)–Prolinamine

Synthesis, spectral and antibacterial activity of Co(II), Ni(II) and Zn(II) complexes with 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H‐naphthalen‐1‐ylidene)‐hydrazide

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