Synthesis, structural characterization, in vitro anti-proliferative effect and cell cycle analysis of N-(ferrocenyl)benzoyl dipeptide esters

Synthesis, Structure, Electrochemistry, and Cytotoxic Properties of Ferrocenyl Ester Derivatives

“…found that increasing the hydrophilicity of the polyaspartimide side chains does not necessarily improve the cytotoxicity of the resulting ferrocenes, similar to our findings [28]. On the other hand, opposite to our findings, Kenny et al studied the antiproliferative effect of a series of N-(ferrocenyl)benzoyl dipeptide esters on H1229 lung cancer cells and found that increasing the alkyl chain length of the amino acid lower the cytotoxic activity [29]. However, since the data come from different cancer cell lines, the comparison of the IC 50 values becomes less accurate.…”

Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety

“…In our experiments, opposite to these conclusions, we found that serine and tyrosine derivatives 1i and 1j having polar hydroxyl groups proved to be less active than compounds bearing aromatic and especially heteroaromatic rings suggesting that lipophilic character could be diminished in comparison with planar aromatic requirements of amino acid part of molecule. Some interesting findings were reported for a series of N-(ferrocenyl) benzoyl dipeptide esters demonstrating the lowering of cytotoxic activity in dependence on increasing of amino acid alkyl chain length [48]. However, all these data come from different cancer cell lines making the difficulty in accordance of their IC 50 values with our results.…”

Magnetic NiFe2O4 nanoparticles: efficient, heterogeneous and reusable catalyst for synthesis of acetylferrocene chalcones and their anti‐tumour activity

“…This can be accomplished by disrupting the function of DNA, either by acting directly on DNA (alkylating agents) or by inhibiting the enzymes involved in DNA synthesis using antimetabolites. Alternatively, chemotherapeutics may act by interfering with the mechanics of cell division, for example by binding to microtubules …”