Synthesis, structural characterization, crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines

The synthesis of new pyrazolo[1,5-a]pyrimidine derivatives

“…The pyrazolopyrimidine derivatives are an important class of heterocyclic compounds with pharmacological and biological activities, such as the antibacterial, 1 antiviral, 2 cytotoxic, 3 antidepressant, 4 neuroleptic, 5 tuberculostatic, 6 antihypertensive, 7 analgesic 8 and antimicrobial activity. 9 The pyrazolo [1,5-a]pyrimidines as bicyclic heterocycles have an important synthetic value in the preparation of drugs with anticancer activities.…”

Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase andα-glucosidase inhibition

“…Heterocyclic compounds containing 1,2,4-triazole skeleton are known to possess a wide range of pharmacological activities such as antimicrobial, antitubercular, anti-inflammatory, antiviral, antioxidant, antidepressant, anticonvulsant, antimalarial, anti-diabetic, anti-obesity, enzyme inhibitory and anticancer activities [14][15][16][17] . Some present day drugs such as fluconazole, itraconazole, terconazole (antifungal agents), anastrozole, letrozole, vorozole (aromatase inhibitors in the treatment of postmenopausal breast cancer), ribavirin (antiviral agent), etoperidone and nefazodone (antidepressant), rizatriptan (antimigraine agent) and rilmazafon (hypnotic, anxiolytic, used in the case of neurotic insomnia) are examples of potent bioactive molecules possessing 1,2,4-triazole moieties 16,[18][19][20][21] . Similarly, heterocyclic compounds bearing 1,3,4-oxadiazole nucleus are also known to possess a wide spectrum of pharmacological properties, including analgesic, anti-inflammatory, antimicrobial, antifungal, anti-convulsant, anti-diabetic, antihelmintic, hypo-glycemic, antiallergic, enzyme inhibitors, antineoplastic, CNS depressant, antitubercular and anticancer [22][23][24][25][26] .…”

Synthesis and <i>in Vitro</i> Biological Activities of 4,5-Disubstituted 1,2,4-Triazole-3-Thiols

“…In the past few decades, the chemistry of 1,2,4-triazoles and their fused heterocyclic derivatives have received considerable attention owing to their diverse synthetic as well as biological importance. A large number of 1,2,4-triazole-containing ring systems, have been incorporated into a wide variety of therapeutically interesting drug candidates having anti-inflammatory, CNS-stimulant, sedative, antianxiety and antimicrobial agents [1,2] and antimycotic activity such as fluconazole, intraconazole, and voriconazole [3]. Many drugs are known containing 1,2,4-triazole moiety for example triazolam [4], alprazolam [5] etizolam [6] and furacylin [7].…”