Synthesis, structural characterization, computational studies and stability evaluations of metal ions and ZnONPs complexes with dimercaptosuccinic acid

Abstract

Meso-2,3-dimercaptosuccinic acid (DMSA) is one of the efficient chelating reagents for treating the toxicity of several heavy metals. Currently, nanomaterial have been applied to various parts including zinc Oxide nanoparticles (ZnONPs). ZnONPs have several properties and are used as many applications. An increasing the amount of ZnONPs in commercial products causes risks related to free radicals or reactive oxygen species (ROS) in the body, leading to oxidative stress and eventually to the cancer process. In the present work, we mainly focused on the study of DMSA complexes in term of metal ions and nanoparticles. The synthesis of DMSA-ZnONPs by the coprecipitation method were determined, followed by Scanning Electron Microscope, Fourier Transform Infrared Spectroscopy and UV-Vis spectrophotometry confirming successful synthesis process. The stability study of the DMSA complexes with metal ions and ZnONPs were determined and evaluated the stability constant (K), with the Benesi-Hildebrand equation. All complexes with DMSA were formed at a 1:2 ratio by the dithiol group and the carboxyl group with different stability constants. Therefore, these results can help of an understanding of the interaction and its behavior between DMSA with heavy metal ion and ZnONPs. In addition, the stable structure of DMSA and metal ion complexes were predicted using the B3LYP and the 6-31G (d,p) basis set which the most stable structure of meso-DMSA was 2R,3S conformation and the metal ions and DMSA complexes was complex 2a with the binding energy of -1553.46 kcal mol À1 .

Influence of Magnetic Nanoparticle Degradation in the Frame of Magnetic Hyperthermia and Photothermal Treatments

“…Moreover, C–H bands at 2850 and 2918 cm –1 were also identified for that coating. In contrast, the NPs@DMSA sample showed the characteristic CO stretching bands at 1431 and 1643 cm –1 and C–O stretching bands at 1106 cm –1 (Figure C) …”

“…In contrast, the NPs@DMSA sample showed the characteristic C�O stretching bands at 1431 and 1643 cm −123 and C−O stretching bands at 1106 cm −1 (Figure 1C). 24 Field-dependent magnetization of the two types of particles showed a superparamagnetic behavior at room temperature (Figure 1D). Although particles had a different coating, as the iron oxide cores from both particles came from the same synthetic batch, the results plotted per mass of magnetite were the same; in both cases, similar remanent magnetization (M r ≈ 4 A m 2 /kg Fed 3 Od 4 ), coercive field (H c ≈ 793 A/m), and saturation magnetization (M s ≈ 78 A m 2 /kg Fed 3 Od 4 ) values were obtained.…”