Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand

Abstract

We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, 1H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand.

Nano‐synthesis, solid‐state structural characterization, and antimicrobial and anticancer assessment of new sulfafurazole azo dye‐based metal complexes for further pharmacological applications

“…In most cases, novel metal sulfonamide chelates demonstrate much efficacy than the medications that they were derived from. [9] Furthermore, the azo dyes have also been shown to exhibit a wide range of biovitality, including antiviral, [10] antibacterial, [11] and antiinflammatory properties. [12] They have been applied extensively in a variety of fields, including printing systems and optical storage technology (CDs and DVDs).…”

Cu(II) and Co(II) Schiff‐Base Complexes Immobilized on Layered Double Hydroxide: Synthesis, Characterizations, DFT Calculations and Catalytic Activity

“…[55] The energy of the HOMO also reveals the electrophilic site of the molecule while the energy of LUMO suggests the nucleophilic site of the molecule. [57] The HOMO orbital primarily acts as an electron donor, while the LUMO orbital primarily acts as an electron acceptor, and the energy gap (ΔE) between the two orbitals describes molecular chemical stability, the smaller the energy easily it would be exciting. [58] Cu(II) and Co(II) Schiff base complexes have HOMO-LUMO gap (ΔE) of 3.86 and 2.75 eV, respectively.…”

Synthesis, Characterization and Evaluate the Biological Activity of Novel Heterocyclic Derivatives from Azomethine Compounds

“…Equimolar mixtures 0.01 mole of aromatic amines and 0.02 mole of aromatic aldehydes dissolved in 25 mL absolute ethanol was placed in a 100 mL round-bottom flask. 3-4 drops of glacial acetic acid was added as catalyst, the mixture was allowed to react at reflux temperature for 4 h and then let to cool down to the room temperature, the progress of the reaction and the purity of the compounds were monitored with TLC technique, whereby a crystalline solid was separated out and recrystallized from ethanol, the structural formula, names, melting points, colors and percentage of yields for the synthesized azomethine compounds R 1 -R 4 are recorded [8][9][10][11][12] .…”