Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

Ohorodnik, Yulia M.; Alexander, Sikalov A.; Khomenko, Dmytro M.; Doroshchuk, Roman O.; Raspertova, Ilona V.; Shova, Sergiu; Babak, Maria V.; Lampeka, R. D.

doi:10.1007/s11243-022-00503-w

Cited by 5 publications

(1 citation statement)

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“…In our ongoing project exploring the rich potential of 1,2,4triazoles in coordination and supramolecular chemistry, a number of new metal complexes bearing 3-(pyridin-2-yl)-1,2,4-triazole derivatives as ligands were prepared. The Cu II , Ru II , Pd II , Eu III , Tb III and Pt II compounds revealed promising magnetic (Petrenko et al, 2021), catalytic (Zakharchenko et al, 2019) and luminescent properties (Khomenko et al, 2015(Khomenko et al, , 2023, as well as antiproliferative activity against several human cancer cell lines (Ohorodnik et al, 2022(Ohorodnik et al, , 2023.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Zakharchenko,

Khomenko,

Doroshchuk

et al. 2024

Acta Cryst E

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The new palladium(II) complex, [Pd(C16H16N4O3)2](CF3COO)2·2CF3COOH, crystallizes in the triclinic space group P\overline{1} with the asymmetric unit containing half the cation (PdII site symmetry Ci ), one trifluoroactetate anion and one co-crystallized trifluoroacetic acid molecule. Two neutral chelating 2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine ligands coordinate to the PdII ion through the triazole-N and pyridine-N atoms in a distorted trans-PdN4 square-planar configuration [Pd—N 1.991 (2), 2.037 (2) Å; cis N—Pd—N 79.65 (8), 100.35 (8)°]. The complex cation is quite planar, except for the methoxo groups (δ = 0.117 Å for one of the C atoms). The planar configuration is supported by two intramolecular C—H...N hydrogen bonds. In the crystal, the π–π-stacked cations are arranged in sheets parallel to the ab plane that are flanked on both sides by the trifluoroacetic acid–trifluoroacetate anion pairs. Apart from classical N/O—H...O hydrogen-bonding interactions, weak C—H...F/N/O contacts consolidate the three-dimensional architecture. Both trifluoroacetic moieties were found to be disordered over two resolvable positions with a refined occupancy ratio of 0.587 (1):0.413 (17) and 0.530 (6):0.470 (6) for the protonated and deprotonated forms, respectively.

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Zakharchenko,

Khomenko,

Doroshchuk

et al. 2024

Acta Cryst E

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Structure and Peculiarities of ¹H NMR‐Spectra of Palladium(II) Complexes with 3‐(2‐pyridyl)‐5‐Alkyl‐1,2,4‐triazoles

Ivanova,

Khomenko,

Doroshchuk

et al. 2024

ChemistrySelect

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A series of chelating N N proligands, 3‐(2‐pyridyl)‐5‐alkyl‐1,2,4‐triazoles (HLAlk), where alkyl=methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl was used as building blocks for designing of coordination compounds. Their reaction with an equimolar amount of [PdCl2(CH3CN)2] led to formation of series of six novel palladium complexes [Pd(HLAlk)Cl2], in which ligands are coordinated in the acid form. New proligands and Pd(II) complexes were characterized by IR, 1H and 13C NMR spectroscopy and elemental analysis. The Pd(II) complexes showed an unusual downfield shift in 1H NMR of the aliphatic proton that is the closest to triazole ring, which suggests the C−H…Cl hydrogen bonding, supported by X‐ray data for Pd(HLc−Pr)Cl2 and Pd(HLc−Bu)Cl2.

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Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles

Ohorodnik

Khomenko

Doroshchuk

et al. 2023

Inorganica Chimica Acta

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Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

Cited by 5 publications

References 31 publications

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Structure and Peculiarities of ¹H NMR‐Spectra of Palladium(II) Complexes with 3‐(2‐pyridyl)‐5‐Alkyl‐1,2,4‐triazoles

Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles

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Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

Cited by 5 publications

References 31 publications

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Crystal structure of bis{2-[5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]pyridine}palladium(II) bis(trifluoroacetate) trifluoroacetic acid disolvate

Structure and Peculiarities of 1H NMR‐Spectra of Palladium(II) Complexes with 3‐(2‐pyridyl)‐5‐Alkyl‐1,2,4‐triazoles

Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles

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Structure and Peculiarities of ¹H NMR‐Spectra of Palladium(II) Complexes with 3‐(2‐pyridyl)‐5‐Alkyl‐1,2,4‐triazoles