Synthesis, structural analysis, in vitro antioxidant, antimicrobial activity and molecular docking studies of transition metal complexes derived from Schiff base ligands of 4-(benzyloxy)-2-hydroxybenzaldehyde

Devi, Jai; Kumar, Sanjeev; Kumar, Binesh; Asija, Sonika; Kumar, Ashwani

doi:10.1007/s11164-021-04644-y

Cited by 49 publications

(26 citation statements)

References 64 publications

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“…2 E 2g (ν 2 ) transitions, respectively, and additionally, the Cu (II) complexes having one unpaired electron with magnetic moment value 1.82-1.92 BM that corresponds to an octahedral geometry. 53 The only intense band observed in the electronic spectra of zinc (II) complexes was due to LMCT, which lies in the range of 23,450-23,870 cm À1 and confirms the octahedral coordination of Zn (II) complexes. Additionally, Zn (II) complexes having fully filled d 10 configuration do not display any d-d transitions.…”

Section: Electronic Spectra and Magnetic Susceptibilitymentioning

confidence: 62%

Spectroscopic studies, antimicrobial activity, and computational investigations of hydrazone ligands endowed metal chelates

Arora,

Devi,

Dubey

et al. 2023

Applied Organom Chemis

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Our current efforts are aimed to synthesize 16 complexes of Co (II), Ni (II), Cu (II), and Zn (II) metal ions from heterocyclic hydrazone ligands by condensation reaction of 2,6‐diacetylpyridine with hydrazide derivatives to find out combating agent against microorganism diseases. The synthesized compounds were precisely characterized by various physicochemical and spectroscopic techniques like FT‐IR, UV–Vis, 1H and 13C NMR, magnetic susceptibility, ESR, mass spectrometry, powder XRD, TGA, and SEM that suggested the octahedral geometry of the complexes coordinating via enolic oxygen atoms, azomethine nitrogen atom, pyridine ring nitrogen atom of the hydrazone ligands, and oxygen atom of water molecule. The thermal stability of the complexes was demonstrated by thermal analysis revealing two‐step decompositions leaving behind metal oxide as an end residue. By using serial dilution method, the compounds (1–20) were tested for in vitro antimicrobial activity against four bacterial and two fungal pathogens. Among all the synthesized compounds, complex 16 was most active against B. subtilis, whereas complexes 13, 14, and 15 were most efficient for C. albicans. Moreover, the biological efficacy of H2L3 (3) ligand and its (13–16) complexes were demonstrated by computational methods like molecular docking, MESP, DFT, and ADMET studies that highlight that complexes have more potency than the ligands and may be employed as effective drug for pathogen‐induced malformations.

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Section: Electronic Spectra and Magnetic Susceptibilitymentioning

confidence: 62%

Spectroscopic studies, antimicrobial activity, and computational investigations of hydrazone ligands endowed metal chelates

Arora,

Devi,

Dubey

et al. 2023

Applied Organom Chemis

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“…In vitro antimicrobial evaluation of the compounds was tested against the bacterial strains that is, two Gram positive: Bacillus subtilis (MTCC 8561) and Staphylococcus aureus (MTCC 2901), two Gram negative: Pseudomonas aeruginosa (MTCC 424) and Escherichia coli (MTCC 16521), and two fungal strains: Candida albicans (MTCC 227) and Aspergillus niger (MTCC 8189), which were cultured on potato dextrose broth (PDB) and nutrient broth (NB) by the standard serial dilution method as per procedure reported in our previous papers. [36] 2.3 | Cytotoxic assay…”

Section: Antimicrobial Assaymentioning

confidence: 99%

Synthesis, characterization, in vitro antimicrobial and cytotoxic studies of Co(II), Ni(II), Cu(II), and Zn(II) complexes obtained from Schiff base ligands of 1, 2, 3, 4‐tetrahydro‐naphthalen‐1‐ylamine

Devi

Sharma

Kumar

et al. 2022

Applied Organom Chemis

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The transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with bidentate Schiff base ligands (HL1−5) were obtained from condensation of 1, 2, 3, 4‐tetrahydro‐naphthalen‐1‐ylamine with methanolic solution of 3‐hydroxy‐salicylaldehyde, 4‐hydroxy‐salicylaldehyde, 5‐bromo‐salicylaldehyde, 3,5‐dibromo‐salicylaldehyde, and 2‐hydroxy‐1‐napthaldehyde. The synthesized compounds were structurally elucidated by spectral and physical methods. The spectral characterization emphasized bidentate nature (NO) of Schiff base ligands which gets chelated with metal via nitrogen atom of imine group and deprotonated oxygen of salicylaldehyde/2‐hydroxy‐1‐napthaldehyde group to form octahedral geometry around metal atom. Thermal results supported that the complexes are stable upto 200°C leaving metal oxide as an end products. The reported compounds (1–25) in this series were screened against the bacterial strains, that is, two Gram positive: Bacillus subtilis and Staphylococcus aureus, two Gram negative: Pseudomonas aeruginosa and Escherichia coli, and two fungal strains: Candida albicans and Aspergillus niger and their results that indicated moderate to good activity with compounds 20 and 21 having good antimicrobial activity (minimum inhibitory concentration [MIC] value 0.0269–0.0067 μmol/ml) as compared with control drugs ciprofloxacine and fluconazole. Furthermore, cytotoxic studies of synthesized compounds were carried out against three human cancer cell lines: HCT‐116 (colon), A549 (alveolar), and MCF‐7 (breast) using standard drug paclitaxel. The results demonstrated that compounds 1 (IC50 values = 12.93, 15.13, 17.24), 3 (11.9, 9.29, 12.64), 9 (17.06, 20.06, 22.87), 14 (16.21, 18.47, 20.00), and 25 (17.54, 17.21, 20.23) for three cancer cell lines were found to be most potent candidates among the synthesized compounds.

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“…The biological efficacy of Schiff bases has been evaluated and demonstrated efficacy, against many cancer diseases, anti-microbial (Venkateswarlu et al, 2022), anti-tuberculosis (Jameel and Sheat, 2013), anti-AIDS (Kar et al, 2022). most of the heterocyclic organic compounds have biological activity (Devi et al, 2022). Some tetrazole compounds have been used as anti-inflammatory and antiviral agents (Myznikov et al, 2022), in addition to being used as herbicides, anti-fungal, and antibacterial.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases

Ghanim¹,

Omar²

2023

RJS

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The present work involves the new chalcones containing Schiff bases, In this study, firstly, reaction of 3-acetylcoumarin with terephthaldehyde to prepared chalcones which contains a free aldehyde group which has been reacted with (4-Aminoantipyrine) to prepare Schiff bases, which was reacted (sodiumazide) as precursor to form (Tetrazole) followed by condensation of these chalcones with some compounds (hydroxylamine, aminophenol, phenylenediamine, hydrazine, semicarbazide, thiosemicarbazide, urea, thiourea and quanidine) as precursor to form Isoxazole, oxazepane, diazepine, pyrazoles and pyrimidine derivatives in basic medium using classical and ultrasonic technique. The comparison of the classical methods with ultrasonic methods. Was achieved. The compositions of the prepared compounds were confirmed by FT-IR and 1 H NMR spectroscopy.

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Synthesis, structural analysis, in vitro antioxidant, antimicrobial activity and molecular docking studies of transition metal complexes derived from Schiff base ligands of 4-(benzyloxy)-2-hydroxybenzaldehyde

Cited by 49 publications

References 64 publications

Spectroscopic studies, antimicrobial activity, and computational investigations of hydrazone ligands endowed metal chelates

Spectroscopic studies, antimicrobial activity, and computational investigations of hydrazone ligands endowed metal chelates

Synthesis, characterization, in vitro antimicrobial and cytotoxic studies of Co(II), Ni(II), Cu(II), and Zn(II) complexes obtained from Schiff base ligands of 1, 2, 3, 4‐tetrahydro‐naphthalen‐1‐ylamine

Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases

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