Synthesis, spectroscopic, thermal decomposition, DFT studies and antibacterial activity of uracil cobalt(III)dimethylglyoximato complexes

Berradj, Omar; Bougherra, Hadda; Adkhis, A.; Amrouche, Tahar; Amraoui, Nour Elyakine; Hammoutène, Dalila

doi:10.1016/j.molstruc.2021.130040

Cited by 3 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results have shown that the synthesised compound 41 exhibited good proliferative activity in vitro with proliferation index of 25 % as compared to the control 6-methyl uracil with proliferation index ranging between 0.00 � 0.07 % respectively. Berradj et al [46] synthesised three new mixed ligand complexes of the type 44 a-c i. e. cobalt(III)dimethylglyoximato complexes [Co(Hdmg) 2 (Ura)X] using dimethylglyoxime 42 as a primary ligand (bidentate) and uracil 43 as the secondary ligand (monodentate) (Scheme 12). The synthesised mixed complexes were then tested for its anti-microbial activity in vitro against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Staphylococcus aureus and Bacillus cereu involved in human pathology and food spoilage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Uracil: A Pharmacophore with Diverse Biological Potential

Jain,

Sharma,

Utreja

2024

ChemistrySelect

View full text Add to dashboard Cite

This review article delves into the intricate biological activities of uracil, an essential pyrimidine Base pivotal in RNA structures. Examining its involvement in nucleic acid metabolism, various multifunctional roles, spanning from influencing cell proliferation to its antimicrobial and antiviral properties. The study explores signal transduction pathways affected by uracil, unraveling potential therapeutic applications. By unraveling the nuanced biological mechanisms. This review contributes to a deeper understanding of uracil's impact, offering insights crucial for drug development and advancing biomedical research.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Berradj et al [46] . synthesised three new mixed ligand complexes of the type 44 a – c i. e. cobalt(III)dimethylglyoximato complexes [Co(Hdmg) 2 (Ura)X] using dimethylglyoxime 42 as a primary ligand (bidentate) and uracil 43 as the secondary ligand (monodentate) (Scheme 12).…”

Section: Introductionmentioning

confidence: 99%