Synthesis, Spectroscopic Studies and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zr(IV) Complexes of Azo Dyes and Thiamine Hydrochloride as Antimicrobial Agents

Abstract

Four series of novel mixed ligand-drug complexes of thiamine hydrochloride as a primary ligand and four azo compounds, as secondary ligands, were prepared using Co (II), Ni (II), Cu (II) and Zr (IV) ions. The complexes were characterized by elemental analysis, thermogravimetric analysis, molar conductivity, FT-IR, magnetic susceptibility and UV-Visible spectroscopy. Based on the analytical and spectral data, the complexes were formulated as [Azo -M -Thiamine (H 2 O) n ] + Cl -where n=2 for Co (II), Ni (II) and Cu (II) and=1 for Zr (IV). All the complexes possessed octahedral geometry in which both the primary and secondary ligands act as monovalent monodentate coordinated via ON fashion in case of azo compounds and via OS fashion in case of thiamine hydrochloride. Biological activity of some complexes has been evaluated against a number of pathogenic bacteria and fungi. Obtained results indicated that the metal complexes exhibited better antimicrobial and antifungal activities.

Graphitic Carbon Nitride Modified with Zr-Thiamine Complex for Efficient Photocatalytic CO2 Insertion to Epoxide: Comparison with Traditional Thermal Catalysis

“…As depicted in Figure e, the Zr 3d exhibits two peaks at 185.0 and 182.7 eV, which correspond to the 3d 3/2 and 3d 5/2 electronic configurations of zirconium, respectively, present in Zr-Thia(75)/g-CN. The energy difference between 3d 3/2 and 3d 5/2 spin–orbit doublet is in agreement with the existence of Zr 4+ species. − The 3d 3/2 and 3d 5/2 peaks are located at higher binding energy than the bulk ZrO 2 (184.5 and 181.5 eV) . This suggests that no ZrO 2 phase is present in the material.…”