Synthesis, spectroscopic, molecular orbital calculation, cytotoxic, molecular docking of DNA binding and DNA cleavage studies of transition metal complexes with N-benzylidene-N′-salicylidene-1,1-diaminopropane

Al‐Mogren, Muneerah Mogren; Alaghaz, Abdel‐Nasser M.A.; Ebrahem, Ebrahem A.

doi:10.1016/j.saa.2013.05.079

Cited by 38 publications

(35 citation statements)

References 43 publications

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“…The observed magnetic moment of the Cu(II) complex is 2.21 B.M., which confirms the octahedral structure of this complex [15,18]. For octahedral Cu(II) complex, the expected transition is 2B1g→2A1g with respective absorption at 15,398 cm −1 .…”

Section: Electronic and Magnetic Moment Measurementssupporting

confidence: 70%

“…These bands may be assigned to 3A2g(F)→3T2g(F)(ν1), 3A2g(F)→ 3T1g(F)(ν2) and 3A2g(F) →3T1g(P)(ν3) transitions, respectively. It suggests octahedral geometry of Ni(II) complex [15,18].…”

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 89%

“…These bands may be assigned to following transitions 4T1g →4T2g(F) (ν1), 4T1g → 4A2g(F) (ν2) and 4T1g → 4T1g(P) (ν3), respectively. The position of bands suggest octahedral geometry of Co(II) complex [18].…”

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 94%

“…for complex (4) at room temperature where that of the usual octahedral complexes are 4.8-5.4 B.M [15,18]. The electronic spectrum of the Co(II) complex displays three bands at 13,256, 15,856 and 24,477 cm −1 .…”

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 94%

“…The magnetic moment was measured which gave 3.24 B.M., for complex (5), which lies in the range (2.9-3.3 μB) of the Ni(II) octahedral complexes [15,18]. Electronic spectrum of Ni(II) complex displays bands at 14,439, 15,225 and 21,745 cm −1 .…”

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 99%

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Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Abdou¹,

Faheim²,

Alaghaz³

2013

Curr Synthetic Sys Biol

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Complexes of cobalt(II), nickel(II), copper(II), zinc(II) and Hafnium(II) of general composition [M(L)2(Cl)2] [L = 4-(phenylphosphinylideneamino-N-thiazolyl benzene-sulfonamide] have been synthesized. The elemental analysis, molar conductance measurements, magnetic susceptibility measurements, mass, IR, UV, NMR, SEM, EDX, thermal and EPR spectral studies of the compounds led to the conclusion that the ligand acts as a bidentate manner. The molar conductance of the complexes in fresh solution of DMSO lies in the range of 7.46-9.13 Ω -1 cm 2 mol -1 indicating their non-electrolytic behavior. On the basis of analytical and spectroscopic techniques, octahedral geometry of the complexes was proposed. The ligand binds in a bidentate manner, coordinated through sulfonamide oxygen and thiazole nitrogen atoms. The ligand field parameters were calculated for Co(II), Ni(II) and Cu(II) complexes and their values were found in the range reported for a octahedral structure. The catalytic activities of the divalent metal complexes have been studied in the oxidation of cyclohexane by hydrogen peroxide, an environmental friendly oxidant. The molecular modeling parameters of the ligand and its Co(II) and Hf(II) complexes have been calculated.

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Section: Electronic and Magnetic Moment Measurementssupporting

confidence: 70%

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 89%

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 94%

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 94%

Section: Electronic and Magnetic Moment Measurementsmentioning

confidence: 99%

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Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Abdou¹,

Faheim²,

Alaghaz³

2013

Curr Synthetic Sys Biol

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Synthesis, characterization, biological activity, and corrosion inhibition in acid medium of unsymmetrical tetradentate N₂O₂ Schiff base complexes

Alturiqi

Alaghaz

Zayed

et al. 2018

J Chinese Chemical Soc

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Four divalent metal(II) complexes, namely [Co(II)L(H2O)Cl]·2H2O, [Ni(II)L(H2O)Cl]·4H2O, [Cu(II)L(H2O)Cl]·3H2O, and [Zn(II)L(H2O)Cl]·5H2O, {L = 2‐furan‐2‐ylmethyleneamino‐phenyl‐iminomethylphenol}, were synthesized and characterized by several techniques. The molar conductance measurement of all analyzed complexes in DMSO showed their non‐electrolytic nature. The new Schiff base ligand (HL) acts as tetradentate ligand, coordinated through deprotonated phenolic oxygen, furan ring oxygen, and two azomethine nitrogen atoms. The ligand field parameters were measured for the metal complexes, which were found to be in the range notified for an octahedral structure. The molecular structural parameters of the synthesized HL ligand and its related metal(II) complexes were calculated and correlated with the experimental parameters such as infrared (IR) data. The investigated ligand and metal complexes were screened for their in vitro antimicrobial activities against different types of fungal and bacterial strains. The resulting data confirmed the examined compounds as a highly promising bactericides and fungicides. The antitumor activities of all inspected compounds were evaluated against colon carcinoma (HCT‐116) and mouse myelogenous leukemia carcinoma (M‐NFS‐60) cell lines. The inhibition effect of HL ligand and its isolated complexes on the corrosion carbon in the form of a rod of area 0.35 cm2 in HCl was investigated by measuring the weight loss at 25 °C.

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Novel 13,14‐dimethyl‐5,8‐dioxa‐2,11,13,14‐tetraaza‐1,12‐diphosphabicyclo [10.1.1] tetradecane 1,12‐dioxide ligand and its Ni(II), Co(II), and Cu(II) complexes: Synthesis, characterization, antimicrobial, DNA cleavage, and computational studies

Alaghaz

Aldulmani

2019

J Chinese Chemical Soc

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A novel diazadiphosphetidine ligand derived from the reaction of 2,4‐dichloro‐1,3‐dimethyl‐1,3,2,4‐diazadiphosphetidine‐2,4‐dioxide and 2,2′‐(ethane‐1,2‐diylbis[oxy])bis(ethan‐1‐amine) and its Ni(II), Cu(II), and Co(II) complexes have been synthesized, characterized by spectroscopic, elemental analyses, magnetic susceptibility, and conductivity methods, and screened for antimicrobial, DNA binding, and cleavage properties. Spectroscopic analysis and elemental analyses indicate the formula [M(H2L)Cl2] for the Cu(II), Co(II), Ni(II), and Zn(II) complexes and octahedral geometry for all the complexes. The non‐electrolytic nature of the complexes in dimethyl sulfoxide (DMSO) was confirmed by their molar conductance values, which are in the range 12.32–6.73 Ω−1 cm2 mol−1. Computational studies have been carried out at the density functional theory (DFT)‐B3LYP/6‐31G(d) level of theory on the structural and spectroscopic properties of diazadiphosphetidine H2L and its binuclear Cu(II), Co(II), Ni(II), and Zn(II) complexes. Six tautomers and geometrical isomers of the diazadiphosphetidine ligand were confirmed using semiempirical AM1 and DFT method from DMOL3 calculations. The copper complex had the best antibacterial activity against Staphylococcus aureus (ATCC 29213). DNA cleavage activities of the compounds, evaluated on pBR322 DNA by agarose gel electrophoresis in the presence and absence of an oxidant (H2O2) and a free‐radical scavenger (DMSO), indicated no activity for the ligand and moderate activity for the complexes, with the copper complex cleaving pBR322 DNA more efficiently in the presence of H2O2.

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Synthesis, spectroscopic, molecular orbital calculation, cytotoxic, molecular docking of DNA binding and DNA cleavage studies of transition metal complexes with N-benzylidene-N′-salicylidene-1,1-diaminopropane

Cited by 38 publications

References 43 publications

Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Synthesis, characterization, biological activity, and corrosion inhibition in acid medium of unsymmetrical tetradentate N₂O₂ Schiff base complexes

Novel 13,14‐dimethyl‐5,8‐dioxa‐2,11,13,14‐tetraaza‐1,12‐diphosphabicyclo [10.1.1] tetradecane 1,12‐dioxide ligand and its Ni(II), Co(II), and Cu(II) complexes: Synthesis, characterization, antimicrobial, DNA cleavage, and computational studies

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Synthesis, spectroscopic, molecular orbital calculation, cytotoxic, molecular docking of DNA binding and DNA cleavage studies of transition metal complexes with N-benzylidene-N′-salicylidene-1,1-diaminopropane

Cited by 38 publications

References 43 publications

Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Synthesis, Spectral Characterization, Cyclic Voltammetry, Molecular Modeling and Catalytic Activity of Sulfa-Drug Divalent Metal Complexes

Synthesis, characterization, biological activity, and corrosion inhibition in acid medium of unsymmetrical tetradentate N2O2 Schiff base complexes

Novel 13,14‐dimethyl‐5,8‐dioxa‐2,11,13,14‐tetraaza‐1,12‐diphosphabicyclo [10.1.1] tetradecane 1,12‐dioxide ligand and its Ni(II), Co(II), and Cu(II) complexes: Synthesis, characterization, antimicrobial, DNA cleavage, and computational studies

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Synthesis, characterization, biological activity, and corrosion inhibition in acid medium of unsymmetrical tetradentate N₂O₂ Schiff base complexes