Synthesis, spectroscopic, cytotoxic, and DNA binding studies of binuclear 2,2′-bipyridine-platinum(II) and -palladium (II) complexes of meso-α,α′-diaminoadipic and meso-α,α′-diaminosuberic acids

Synthesis, Characterization, DNA Binding and Cytotoxic Studies of Platinum(II) and Palladium(II) Complexes of the 2,2'-Bipyridine and an Anion of 1,1-Cyclobutanedicarboxylic Acid.

“…The yellow precipitate were filtered, washed with small amount of chilled double distilled water and finally recrystallized from double distilled water and dried in vacuum desiccator over anhydrous calcium chloride. Cytotoxic Studies The procedure followed was similar to that reported earlier 18) except that 2ϫ10 6 P 388 lymphocytic leukemia cells per ml were used in place of 1ϫ10 6 P 388 cells per ml in Tris-HCl buffer solution. Binding Studies The difference UV absorption and fluorecence methods were used to determine the binding of metal complexes to DNA as described earlier 18,19) except that the metal complexes-DNA systems were incubated at 37°C for 10 h before spectral measurements.…”

Investigation of effects of newly synthesized Pt(II) complex against human serum albumin and leukemia cell line of K562

“…The preparation of this compound followed the published synthesis for CH3-(CH2)7-NH-CH2-COOH.HCl (28)(29)(30) …”

“…Platinum (II) complexes including cis-platin and carboplatin are widely used in the treatment of several human malignant diseases, such as ovarian, testicular, lung, urinary bladder, head and neck cancer (14,15). Previous reports have been represented that the binding of platinum complexes to the N7-nitrogens of two adjacent guanosine bases is thought to disrupt DNA duplication leading to cell death.…”

A Thermodynamic Study on the Binding of Human Serum Albumin with New synthesized Anticancer Pd(II) Complex

“…Pd (II) complexes are expected to have lower kidney toxicity than cisplatin due to the inability of proteins in the kidney tubules to replace the tightly bound chelate ligands of Pd (II) with sulfydril groups [14][15][16][17] . Studies have shown that Pd (II) complexes are very effective in inhibiting proliferation in several tumor cell lines [18][19][20][21] .…”