Synthesis, spectroscopic characterization, DFT studies and antibacterial assays of a novel silver(I) complex with the anti-inflammatory nimesulide

Enhanced performance of a metal-organic framework analogue to MIL-101(Cr) containing amine groups for ibuprofen and nimesulide controlled release

“…The spectra of NMS showed bands relative to SO 2 group that correspond to ν as and ν sym at 1342 cm − 1 and 1153 cm −1 , respectively. Bands relative to the NO 2 group are observed at 1515 and 1318 cm − 1 , corresponding to ν ass and ν sym , respectively [21]. The appearance of the bands in IR spectra of the materials in 1340 and 1157 cm −1 for SO 2 group and 1508 cm −1 for NO 2 group confirmed the incorporation of NMS.…”

Silver sulfadoxinate: Synthesis, structural and spectroscopic characterizations, and preliminary antibacterial assays in vitro

“…The heteronuclear [ 1 HA 13 C] single quantum coherence (HSQC), heteronuclear [ 1 HA 13 C] multiple bond coherence (HMBC) and the heteronuclear [ 1 HA 15 N] multiple bond coherence (HMBC) spectra of SFX were acquired on a Bruker Avance 400 MHz, using a 5-mm probe at 303 K, operating at 40.5 MHz for 15 N; samples were was prepared in deuterated dimethylsulfoxide solutions. The solid state nuclear magnetic resonance (SS-NMR) 13 C spectrum of SFX an AgSFX was recorded on a Bruker 400 MHz Avance II (9.395T) operating at 100 MHz using cross polarization, proton decoupling and magic angle spinning (CP/MAS). The solid-state 15 N{ 1 H} nuclear magnetic resonance spectra were recorded on a Bruker 400 MHz, using the combination of cross-polarization, proton decoupling and magic angle spinning (CP/MAS) at 6 kHz.…”

“…After one hour of constant stirring at room temperature, a white solid precipitated and was collected by filtration, washed with cold water, and dried in a desiccator with P 4 13.0. AgSFX is poorly soluble in water, DMSO, DMF, chloroform, acetonitrile, hexane, ethanol and methanol.…”

“…For example, a silver complex with N-acetyl-L-cysteine was recently synthesized, and showed a broad spectrum of activity against microorganisms [12]. In addition, a silver complex with the antiinflammatory drug nimesulide (another sulfonamide) [13] was shown to be active against Gram-positive and Gram-negative bacteria. Moreover, the Ag(I) derivatives are currently being investigated as anticancer drugs [12,14].…”

Biomimetic synthesis of proline-derivative templated mesoporous silica for increasing the brain distribution of diazepam and improving the pharmacodynamics of nimesulide

“…belonging to the stretching vibration of C ¼ N (de Paiva et al, 2012). However, in the spectra of 1:3 NMS/CMS, the peaks of benzene ring and secondary amine decreased significantly.…”